Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways

Komaki, Yuichi; Sugiura, Hiroaki; Koarai, Akira; Tomaki, Masafumi; Ogawa, Hiroyasu; Akita, Takefumi; Hattori, Toshio; Ichinose, Masakazu

doi:10.1016/j.pupt.2005.01.002

Cited by 58 publications

(39 citation statements)

References 26 publications

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“…Similarly, interleukin-6, a pleiotropic proinflammatory cytokine, is synthesized by various cell types [21]. Proinflammatory cytokines are capable of inducing more pronounced reactive oxygen species generation by xanthine oxidoreductase/xanthine oxidase [41,42]. In this present study it was found that, as compared to the normal cornea where proinflammatory cytokine expression is nearly absent, after UVB irradiation and buffered saline treatment the proinflammatory cytokines studied were strongly expressed in the corneal epithelium.…”

Section: Discussionsupporting

confidence: 46%

Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression

Čejková

Ardan

Čejka

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Trehalose favorably influenced the oxidative damage of the cornea caused by UVB rays. Trehalose suppressed proinflammatory cytokine induction. It is suggested that suppression of proinflammatory cytokines contributed strongly to reduced matrix metalloproteinase and xanthine oxidase expression in the UVB-irradiated corneal epithelium and to the decreased development of an antioxidant/pro-oxidant imbalance. The overexpression of heat shock protein 70 found in UVB-irradiated cornea after buffered saline treatment was reduced after trehalose application.

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Section: Discussionsupporting

confidence: 46%

Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression

Čejková

Ardan

Čejka

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…Half of all sampled probes were contaminated with blood from bronchial mucosa. The present authors conclude that it is not feasible to sample ELF from peripheral airways in clinical studies investigating asthma patients, in contrast to successful application in acute respiratory distress syndrome and COPD [31,32].…”

Section: Discussionmentioning

confidence: 72%

Ciclesonide improves measures of small airway involvement in asthma

Cohen

Douma²,

Hacken³

et al. 2008

European Respiratory Journal

103

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Ciclesonide is delivered as a small-particle inhaled corticosteroid and improves lung function and airway hyperresponsiveness. The objective of the present study was to assess whether ciclesonide can specifically improve small airway function in asthma.A total of 16 mild-to-moderate asthma patients (seven males; median (range) age 39 (19-56) yrs and forced expiratory volume in one second (FEV1) 89 (62-120)% predicted) were randomised to 5 weeks' treatment with placebo or 320 mg ciclesonide once daily. The following small airway parameters were assessed: mean forced expiratory flow between 25 and 75% of forced vital capacity (FVC), percentage fall in FVC at provocative dose of adenosine-59-monophosphate and of methacholine (MCh) causing a 20% fall in FEV1, expiratory lung volume on computed tomography (CT) scan after MCh challenge, single-breath nitrogen closing volume and alveolar exhaled nitric oxide (eNO).Seven subjects received placebo and nine received ciclesonide. Both alveolar eNO and CT measurements of expiratory lung volume after MCh challenge decreased significantly with ciclesonide (median (range) decrease 4.4 (54.8-1.4) ppb and 59 (1,569--117) mL, respectively), and compared with placebo (-0.4 (7.3--3.4) ppb and -121 (20--236) mL respectively). Ciclesonide did not significantly improve other small airways parameters.Inflammation and patency of small airways, reflected by alveolar exhaled nitric oxide and air trapping on computed tomography scan, both improve with ciclesonide even in this small number of patients. This indicates that ciclesonide exerts anti-inflammatory effects on small airways.

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“…A remarkable effect of ciprofloxacin administration noted in the present study was the marked reduction (by ϳ65%) of XO levels in the BALF of ricin-intoxicated mice. XO is one of the most important sources of ROS in multiple pathologies (31), including lung pathologies (32,33). Specifically, it was shown that XO significantly contributes to pulmonary edema formation following ischemia/reperfusion (I/ R), via direct ROS-induced pulmonary endothelium injury (21), as well as following LPS administration (20).…”

Section: Discussionmentioning

confidence: 99%

Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis

Gal

Sapoznikov

Falach

et al. 2016

Antimicrob Agents Chemother

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The plant toxin ricin is considered a biological threat agent of concern and is most toxic when inhaled. Pulmonary exposure to a lethal dose of ricin can be redressed by treatment with antiricin antibodies; however, late antitoxin intervention is of limited efficacy. This limitation is associated with overt lung damage, clinically manifested as severe pulmonary inflammation, which develops over time. Increased evidence indicates that ciprofloxacin, a broad-spectrum antimicrobial agent, possesses immunomodulatory properties. Here we demonstrate that while antiricin antibody administration at late hours after intranasal exposure to ricin confers limited protection to mice, highly efficient protection can be achieved by adding ciprofloxacin to the antibody treatment. We further demonstrate that parameters associated with lung injury, in particular, pulmonary proinflammatory cytokine production, neutrophil migration, and edema, are sharply reduced in ricin-intoxicated mice that were treated with ciprofloxacin. The presented data highlight the potential clinical application of ciprofloxacin as a beneficial immunomodulatory agent in the course of ricin intoxication. Ricin, a type II ribosome-inactivating protein, is a plant toxin derived from the seeds of Ricinus communis (castor beans). The holotoxin consists of two polypeptide chains (A and B) linked by a disulfide bond. The B chain is a lectin, which binds to galactose residues on the cell surface. The A chain possesses RNA Nglycosidase activity that irreversibly inactivates the 28S rRNA of the mammalian 60S ribosome subunit, subsequently arresting cell protein synthesis (1). Due to its high availability and relative ease of production, ricin is considered a biological threat agent (2). The toxicity of ricin depends on the route of exposure, inhalatory exposure being considered the most severe (3). Pathological studies of pulmonary ricin intoxication have demonstrated that injury is confined mostly to the lungs (4) and characterized by a local cytokine storm, massive neutrophil recruitment, increased prooxidant enzyme activity, and development of proteinaceous pulmonary edema, subsequently resulting in respiratory failure and death (4, 5).Prophylactic antiricin vaccines are being developed (6), yet postexposure medical countermeasures are needed for treatment of unvaccinated victims after pulmonary exposure to lethal doses of the toxin. Previous studies have examined the possibility of protecting animals against pulmonary ricinosis by passive immunization with polyclonal antiricin antibodies; nevertheless, under this mode of protection, survival rates declined sharply in correlation with antitoxin administration timing following intoxication, so that antiricin antibodies administered 24 h after exposure gave rise to limited rates of survival (5, 7). At this late time point, the pathophysiological condition of some of the intoxicated mice may have deteriorated so that the loss of function of the lungs is irreversible. Conversely, we previously showed that higher sur...

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Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways

Cited by 58 publications

References 26 publications

Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression

Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression

Ciclesonide improves measures of small airway involvement in asthma

Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis

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