Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐1 receptor antagonist

Cunha, Joice Maria da; Cunha, Fernando Q.; Poole, Stephen; Ferreira, S. H.

doi:10.1038/sj.bjp.0703434

Cited by 184 publications

(119 citation statements)

References 40 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…They studied the effect of IL-4 on mechanical hyperalgesia evoked by intraplantar injection of carrageenan, bradykinin, and TNF-α in rats. 60,61 In these studies, injection of IL-4 was followed by decreased hyperalgesia and by a reduced production of TNF-α and IL-1β (see Fig. 1B) and by that seemed to attenuate the release of prostaglandins, which is in line with previous findings.…”

Section: Il-4 and Antinociceptive Properties Of Anti-inflammatory Cytsupporting

confidence: 81%

See 1 more Smart Citation

IL-4, JAK-STAT signaling, and pain

Busch-Dienstfertig

González-Rodríguez

2013

JAK-STAT

View full text Add to dashboard Cite

Section: Il-4 and Antinociceptive Properties Of Anti-inflammatory Cytsupporting

confidence: 81%

“…1B) and by that seemed to attenuate the release of prostaglandins, which is in line with previous findings. 62 Besides IL-4, IL-1 receptor antagonist reversed hyperalgesia with similar efficiency 61 (see also Fig. 1B).…”

Section: Il-4 and Antinociceptive Properties Of Anti-inflammatory Cytmentioning

confidence: 90%

IL-4, JAK-STAT signaling, and pain

Busch-Dienstfertig

González-Rodríguez

2013

JAK-STAT

View full text Add to dashboard Cite

“…Both IL-8 and PGE 2 are known to induce hyperalgesia. 25 Micromovement may occur between the vertebral bodies, anteriorly, in the presence of a solid posterior fusion. Graph showing the percentage of disc specimens in each group which produced each mediator.…”

Section: Discussionmentioning

confidence: 99%

Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators

Burke

Watson

McCormack

et al. 2002

The Journal of Bone and Joint Surgery. British volume

332

248

View full text Add to dashboard Cite

H erniated intervertebral disc tissue has been shownto produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain.We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E 2 (PGE 2 ) in disc tissue from patients undergoing discectomy for sciatica (63) with that from patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay.There was a statistically significant difference between levels of production of IL-6 and IL-8 in the sciatica and low back pain groups (p < 0.006 and p < 0.003, respectively).The high levels of proinflammatory mediator found in disc tissue from patients undergoing fusion suggest that production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of a painful lumbar disc. [Br] 2002;84-B:196-201. J Bone Joint Surg Received 8 June 2001; Accepted 3 August 2001The pathophysiology of discogenic low back pain is incompletely understood. 1 The changes which occur as a disc degenerates are well documented, but are unhelpful in determining whether a degenerate disc will cause pain.2 It is known that disc tissue from patients undergoing discectomy for sciatica synthesises proinflammatory mediators and cytokines. 3-12 Sequestrated and extruded discs produce higher levels of these mediators than specimens in which the annulus is intact. 5,10,12,13 To date, there have been no studies of the production of inflammatory mediators in disc tissue from patients undergoing operations for discogenic low back pain. It has been shown, however, that degenerate discs in these patients contain more nociceptive nerve endings in the endplates of the disc and in the nucleus pulposus than do degenerate discs which do not cause low back pain. 14, 15 We have therefore compared levels of production of the proinflammatory mediators tumour necrosis factor alpha (TNF␣), interleukin-1beta (IL-1␤), interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E 2 (PGE 2 ), in disc tissue from patients undergoing discectomy for sciatica with those from patients undergoing fusion for discogenic low back pain. Patients and MethodsWe obtained specimens of intervertebral disc from 63 patients undergoing primary lumbar discectomy for sciatica. Intraoperative assessment of the morphology of the disc herniation revealed 25 in which the annulus was intact (AI), 30 in which a nuclear extrusion was present (EXT) and eight in which the nucleus was sequestrated (SEQ). The mean ages were 42 years in the AI group, 39.5 years in the EXT group and 42 years in the SEQ group. The male: female ratio in the AI, EXT and SEQ groups was 17:8, 20:10 and 6:2, respectively. Three specimens were from the L3/L4 level, 28 from the L4/L5 level and 32 from the L5/ S1 level.We also obtained disc specimens from 20 patients undergoing primary lumbar interbody fusion for discogenic low back pain, which had been confirmed by discograph...

show abstract

“…This test was instrumental in the discovery of various seminal findings, which were later confirmed by other nociceptive methods such as formalin-induced flinches (10,11), chemically induced writhing (12,13) and the classical Randall and Selitto method (14). In fact, the modified Randall and Selitto test was used in several pioneering studies of inflammatory nociceptor sensitization (hypernociception): the participation of the cAMP/Ca 2+ pathway in the mechanism of hypernociception (15), the peripheral effect of opiates (16), the cytokine cascade involved in the onset of inflammatory hypernociception (17)(18)(19)(20)(21)(22)(23)(24), the peripheral memory of nociceptor sensitization (25,26), and the spinal retrograde sensitization of primary sensory neurons (27).…”

Section: Introductionmentioning

confidence: 99%

An electronic pressure-meter nociception paw test for rats

Vivancos

Verri

Cunha

et al. 2004

Braz J Med Biol Res

199

118

View full text Add to dashboard Cite

The objective of the present investigation was to compare the sensitivity of an electronic nociceptive mechanical paw test with classical mechanical tests to quantify the intensity variation of inflammatory nociception. The electronic pressure-meter test consists of inducing the hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer. This method was compared with the classical von Frey filaments test and with the rat paw constant pressure test, a modification of the Randall and Selitto test developed by our group. When comparing the three methods, the electronic pressure-meter and the rat paw constant pressure test, but not the von Frey filaments test, detected time vs treatment interactions in prostaglandin E 2 (PGE 2 )-induced hypernociception. Both methods also detected the PGE 2 -induced hypernociception in dose-(50-400 ng/ paw) and time-(1-4 h) dependent manners, and time vs treatment interactions induced by carrageenin (25-400 µg/paw). Furthermore, the electronic pressure-meter test was more sensitive at early times, whereas the constant pressure test was more sensitive at later times. Moreover, the electronic pressure-meter test detected the dose-dependent antinociceptive effect of local indomethacin (30-300 µg/paw) and dipyrone (80-320 µg/paw) on carrageenin-(200 µg/paw) and PGE 2 -(100 ng/paw) induced hypernociception, respectively, and also detected the ineffectiveness of indomethacin (300 µg) on the effect of PGE 2 . Our results show that the electronic pressure-meter provides a sensitive, objective and quantitative mechanical nociceptive test that could be useful to characterize new nociceptive inflammatory mediators and also to evaluate new peripheral analgesic substances. Correspondence

show abstract

Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐1 receptor antagonist

Cited by 184 publications

References 40 publications

IL-4, JAK-STAT signaling, and pain

IL-4, JAK-STAT signaling, and pain

Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators

An electronic pressure-meter nociception paw test for rats

Contact Info

Product

Resources

About