Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Kruijf, Evert-Jan F. M. de; Fibbe, Willem E.; Pel, Melissa van

doi:10.1111/nyas.14059

Cited by 29 publications

(26 citation statements)

References 144 publications

(340 reference statements)

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“…On the other hand, IL-18 is mainly involved in the Th1 paradigm, inducing the production of IFN-γ, modulating early differentiation of hematopoietic cells and consequently enhancing the production of mature cells to act against infection [ 101 ]. Interestingly, IL-1β and IL-18 released from innate immune cells during inflammasome activation also increase the egress of these cells from the BM, and both cytokines are strong mobilization mediators [ 100 , 102 ]. The release of active IL-1β and IL-18 from cells can provide molecular evidence for inflammasome activation, and other DAMPs are also released in addition to interleukins.…”

Section: Extracellular Signals Activate the Inflammasome Through Pmentioning

confidence: 99%

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Yang

et al. 2021

Molecules

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Hematopoietic stem cells (HSCs) regularly produce various blood cells throughout life via their self-renewal, proliferation, and differentiation abilities. Most HSCs remain quiescent in the bone marrow (BM) and respond in a timely manner to either physiological or pathological cues, but the underlying mechanisms remain to be further elucidated. In the past few years, accumulating evidence has highlighted an intermediate role of inflammasome activation in hematopoietic maintenance, post-hematopoietic transplantation complications, and senescence. As a cytosolic protein complex, the inflammasome participates in immune responses by generating a caspase cascade and inducing cytokine secretion. This process is generally triggered by signals from purinergic receptors that integrate extracellular stimuli such as the metabolic factor ATP via P2 receptors. Furthermore, targeted modulation/inhibition of specific inflammasomes may help to maintain/restore adequate hematopoietic homeostasis. In this review, we will first summarize the possible relationships between inflammasome activation and homeostasis based on certain interesting phenomena. The cellular and molecular mechanism by which purinergic receptors integrate extracellular cues to activate inflammasomes inside HSCs will then be described. We will also discuss the therapeutic potential of targeting inflammasomes and their components in some diseases through pharmacological or genetic strategies.

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Section: Extracellular Signals Activate the Inflammasome Through Pmentioning

confidence: 99%

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Yang

et al. 2021

Molecules

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“…Mobilized peripheral blood (mPB), where clinicians utilize known agents (e.g. granulocyte colony-stimulating factor 4, 5 and/or HSC/HPC retention signal antagonists such as AMD3100 6– 8 ) to release high numbers of HSCs and HPCs into the bloodstream for easy collection, was only in its early stages. In the 1980’s, umbilical CB, usually a discarded material except for routine newborn blood tests, was studied for HSC and HPC biology in a national collaboration 9 .…”

Section: Background: the Beginning Of Cord Blood Transplantationmentioning

confidence: 99%

Past, present, and future efforts to enhance the efficacy of cord blood hematopoietic cell transplantation

et al. 2019

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Cord blood (CB) has been used as a viable source of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) in over 35,000 clinical hematopoietic cell transplantation (HCT) efforts to treat the same variety of malignant and non-malignant disorders treated by bone marrow (BM) and mobilized peripheral blood (mPB) using HLA-matched or partially HLA-disparate related or unrelated donor cells for adult and children recipients. This review documents the beginning of this clinical effort that started in the 1980’s, the pros and cons of CB HCT compared to BM and mPB HCT, and recent experimental and clinical efforts to enhance the efficacy of CB HCT. These efforts include means for increasing HSC numbers in single CB collections, expanding functional HSCs ex vivo, and improving CB HSC homing and engraftment, all with the goal of clinical translation. Concluding remarks highlight the need for phase I/II clinical trials to test the experimental procedures that are described, either alone or in combination.

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“…In mammals, LPS induces HSPC mobilization through its receptor TLR4 and NOD-like receptors (8). Infection and inflammation also upregulate the expression of host-derived cytokines such as G-CSF, which is widely known to mediate HSPC mobilization (48). In this study, we found that LPS regulated HSPC mobilization through CXCR4a, whereas LECT2 regulated HSPC mobilization through CXCR4b and SDF-1 in teleosts.…”

Section: Discussionmentioning

confidence: 50%

CXCR4s in Teleosts: Two Paralogous Chemokine Receptors and Their Roles in Hematopoietic Stem/Progenitor Cell Homeostasis

Zhu

Shen

et al. 2020

The Journal of Immunology

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Hematopoietic stem/progenitor cells (HSPCs) generate the entire repertoire of immune cells in vertebrates and play a crucial role during infection. Although two copies of CXC motif chemokine receptor 4 (CXCR4) genes are generally identified in teleosts, the function of teleost CXCR4 genes in HSPCs is less known. In this study, we identified two CXCR4 genes from a teleost, ayu (Plecoglossus altivelis), named PaCXCR4a and PaCXCR4b. PaCXCR4b was constitutively expressed in ayu HSPCs, whereas PaCXCR4a was induced by LPS treatment. The stromal-derived factor-1-binding activity of CXCR4b was significantly higher than that of CXCR4a, whereas the LPS-binding activity of CXCR4a was significantly higher than that of CXCR4b in the teleosts ayu, large yellow croaker (Larimichthys crocea), and tiger puffer (Takifugu rubripes). CXCR4a + HSPCs were mobilized into blood by LPS, whereas CXCR4b + HSPCs were mobilized by leukocyte cell-derived chemotaxin-2. PaSDF-1 and PaCXCR4b, but not PaCXCR4a, inhibited HSPC proliferation by regulating reactive oxygen species levels. Compared with PaCXCR4b + HSPCs, PaCXCR4a + HSPCs preferentially differentiated into myeloid cells in ayu by maintaining high stem cell leukemia expression. These data suggest that the two copies of CXCR4s achieve a division of labor in the regulation of teleost HSPC homeostasis, supporting the concept that subfunctionalization after gene duplication in teleosts may stabilize the immune system.

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Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Cited by 29 publications

References 144 publications

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Past, present, and future efforts to enhance the efficacy of cord blood hematopoietic cell transplantation

CXCR4s in Teleosts: Two Paralogous Chemokine Receptors and Their Roles in Hematopoietic Stem/Progenitor Cell Homeostasis

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