Cytokine gene polymorphisms in obstructive sleep apnoea/hypopnoea syndrome

Bielicki, Piotr; MacLeod, Andy; Douglas, Neil J.; Riha, Renata L.

doi:10.1016/j.sleep.2015.01.006

Cited by 8 publications

(2 citation statements)

References 21 publications

(24 reference statements)

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“…Although the exact mechanism underlying OSA is unknown, inflammation and oxidative stress are considered to play important roles in the OSA development ( 8 – 14 ). Recent studies have shown that plasma levels of a wide range of proinflammatory mediators are elevated in patients with OSA ( 13 , 15 ). One of the key hallmarks of OSA is intermittent hypoxia (IH) ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

et al. 2018

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Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. This study was designed to evaluate ANGPTL4 and 8 levels in an OSA group and a control group to clarify the effect of OSA on ANGPTL4 and 8 levels.Methods: In total, 74 subjects were enrolled in this study, including 22 age- and body mass index (BMI)-matched controls with the Apnea Hypopnea Index (AHI) score of <5 events/h and 52 subjects with an AHI score of >5 events/h. Sleep apnea was assessed using a portable sleep test. ANGPTL4 and 8 levels were measured in plasma samples using enzyme-linked immunosorbent assay.Results: Mean AHI score (2.5 ± 1.6) in the control group was significantly lower than that in the OSA group (22.9 ± 17.9; p < 0.0001). Leptin, interleukin-(IL) 6, insulin, and HOMA-IR values were higher in the OSA group than in the control group. ANGPTL8 level was higher in the OSA group (1130.0 ± 108.61 pg/mL) than in the control group (809.39 ± 108.78 pg/mL; p = 0.041). Similarly, ANGPTL4 was higher in the OSA group (179.26 ± 12.89 ng/mL) than in the control group (142.63 ±7.99 ng/mL; p = 0.018).Conclusion: Our findings demonstrate that ANGPTL4 and 8 levels were increased in subjects with OSA, suggesting that the upregulation of these lipid metabolism regulators might play a role in lipid dysregulation observed in people with OSA.

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Section: Introductionmentioning

confidence: 99%

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

et al. 2018

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“…43 Cytokine gene polymorphisms, such as TNF-a single-nucleotide polymorphism (À308A), may be associated with OSA in some populations but more studies need to be performed. 45 Bouloukaki et al 46 also looked at serum cytokine levels in patients with OSA and erectile dysfunction and found elevated acute-phase response proteins and cytokines (C-reactive protein, IL-1b, TNF-a, IL-6, and IL-8) and decreased serum adiponectin levels compared with controls. The reduced levels of adiponectin have been associated with increased proinflammatory cytokines and accelerated atherogenesis in several studies.…”

Section: Activation Of Inflammatory Pathwaysmentioning

confidence: 99%

An obstructive sleep apnea primer

Pasha

Kumar

Chatterjee

et al. 2017

Annals of Allergy, Asthma & Immunology

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INSTRUCTIONSCredit can now be obtained, free for a limited time, by reading the review article and completing all activity components. Please note the instructions listed below:Review the target audience, learning objectives and all disclosures.Complete the pre-test.Read the article and reflect on all content as to how it may be applicable to your practice.Complete the post-test/evaluation and claim credit earned. At this time, physicians will have earned up to 1.0 AMA PRA Category 1 Credit TM . Minimum passing score on the post-test is 70%. Overall Purpose Participants will be able to demonstrate increased knowledge of the clinical treatment of allergy/asthma/immunology and how new information can be applied to their own practices. Learning ObjectivesAt the conclusion of this activity, participants should be able to:Recognize patients at high risk for obstructive sleep apnea Recommend appropriate diagnostic tests and treatment for obstructive sleep apnea

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