2007
DOI: 10.1111/j.1399-0039.2007.00917.x
|View full text |Cite
|
Sign up to set email alerts
|

Cytokine gene polymorphisms in Colombian patients with systemic lupus erythematosus

Abstract: Systemic lupus erythematosus (SLE) patients exhibit alterations in cytokine production that may be relevant to SLE pathogenesis. There is evidence that cytokine gene polymorphisms control cytokine production; thus, these polymorphisms may be associated with SLE or its clinical manifestations. To establish the association of tumor necrosis factor alpha (TNF-alpha), transforming growth factor (TGF) beta1, interleukin (IL)-10, and IL-6 gene polymorphisms in Colombian SLE patients and their clinical manifestations… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
39
5

Year Published

2009
2009
2018
2018

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 56 publications
(46 citation statements)
references
References 37 publications
(60 reference statements)
2
39
5
Order By: Relevance
“…This observation again suggests the role of the complex interaction of multiple genes and the involvement of other factors in the development of SLE. Overall, our results do not agree with several other studies carried out on other world populations (10,15,16) and these contradictory results could be due to the genetic heterogeneity of SLE in different ethnicities.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…This observation again suggests the role of the complex interaction of multiple genes and the involvement of other factors in the development of SLE. Overall, our results do not agree with several other studies carried out on other world populations (10,15,16) and these contradictory results could be due to the genetic heterogeneity of SLE in different ethnicities.…”
Section: Discussioncontrasting
confidence: 99%
“…The translation of IL-6 RNA and post-translational processing result in the formation of a 21-to 28-kDa protein with 128 amino acids (14). In the present study, we investigated whether there is an association between SLE susceptibility and single nucleotide polymorphisms located in the promoter region of the IL-6 gene (-174 G/C) in our Malaysian SLE patients, although many negative correlation results have been observed in various studies in the world (10,15,16).…”
Section: Introductionmentioning
confidence: 94%
“…The resulting defects in immune tolerance eventually lead to an abnormal response to self-antigens and the tissue damage seen in diseases such as asthma, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis [4,5,8,9,[16][17][18][19][20]. Bearing in mind the role of defects in selfantigen recognition by T-lymphocytes in autoimmune processes, polymorphisms in the IL-4 gene may lead to a magnification of IL-4 signaling and thus the Th-2 immune response.…”
Section: Discussionmentioning
confidence: 97%
“…One would intuitively choose genes whose products are more likely to be important in the regulation of cellular or humoral immune responses. We focused in this study on IL-4, IL-10 and TGF-b gene polymorphisms, considering that polymorphisms in these three genes have been associated with immune conditions such as atopy, systemic lupus erythematosus and rheumatoid arthritis [4][5][6][7][8][9]. We hypothesized O that these anti-inflammatory mediators might be involved in GD pathogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…Remaining 28 studies were retrieved for more detailed evaluation [11][12][13][14]. Of these, 18 were not conducted in Asian populations and were excluded [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. Thus, 10 studies were selected in PubMed (Table 1) [11][12][13][14][17][18][19][20][21][22].…”
Section: Resultsmentioning
confidence: 99%