Cytokine gene polymorphisms in Asian Indian patients with Takayasu’s Arteritis (TA) – a single center study

Danda, Debashish; Hindhumathi, M.; Ruchika, Goel; Jayakanthan, K.; Jeyaseelan, Lakshmanan; Jeyaseelan, Vishali; Joseph, George; Danda, Sumita

doi:10.1016/j.injr.2014.10.214

Cited by 2 publications

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“…Levels of IL-17 mRNA when elevated in the temporal artery actually predicted sustained responsiveness to glucocorticoid treatment [ 13 ]. IL-17 polymorphisms have been linked to GCA [ 14 ], and more recently in TA [ 15 ]. Studies on pathogenesis of TA are limited by the availability of aortic tissue samples [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis

Misra

Chaurasia

Misra

2016

Autoimmune Diseases

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Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, and IL-17PE), NKT, NK (anti-CD3APC, CD56FITC), and γδT (anti-CD3FITC and γδTCRAPC) cells were enumerated by flow cytometry in peripheral blood of 30 patients with TA (ACR1990 criteria) and 20 healthy controls, serum IL-17 and IL-23 measured by ELISA. Relation with disease activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median with interquartile range). Results. Mean age of patients was 33.47 ± 11.78 years (25 females); mean symptom duration was 7.1 ± 5.3 years. 13 were not on immunosuppressants; 12 were active (ITAS2010 ≥ 4). The percentage of Th17 cells was significantly expanded in TA (patients 2.1 (1.5–3.2) versus controls 0.75 (0.32–1.2); p < 0.0001) with no differences in other cell populations. Serum IL-17 and IL-23 (pg/mL) in patients (6.2 (4.6–8.5) and 15 (14.9–26.5), resp.) were significantly higher (p < 0.001) than controls (3.9 (3.9–7.3) and undetectable median value, resp.). Subgroup analysis revealed no correlation of Th17 cells, serum IL-17, and IL-23 with disease activity or medications, nor any significant difference before and after medication. Conclusions. There is significant expansion of Th17 cells and elevated serum IL-17 and IL-23 levels in TA patients compared to healthy controls.

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Section: Discussionmentioning

confidence: 99%

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis

Misra

Chaurasia

Misra

2016

Autoimmune Diseases

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“…Furthermore, Sandhya et al 14 , Three results were obtained after enzyme digestion of the PCR products. A comprehensive NcoI cut for homozygous TNF-(-308G/G), yielding 2 87 and 20 base pair remains; an incomplete cut for heterozygous TNF-(-308G/A), producing 3 107, 87, and 20 base pair remains; and an un-cut homozygous TNF-(-308A/A), yielding 107 base pair fragments.…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor (TNF)-α-308 gene polymorphism in children of Haemophilia A

Hussein

Bakaa

Flaih

2023

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Hemophilias are the most common X-linked inherited blood diseases that, if not properly treated, can cause lifelong debilitations. The challenges and problems in babies differ from that in older kids and adults. Blood loss conditions continue to dominate as diagnostic triggers in children, but the locations of blood loss vary with age. The TNF-α-308 gene polymorphism in children with moderate to severe hemophilia correlates with genetic background and with the clinical phenotype of the cases. This study was a case control conducted in fifty hemophilic and fifty age- and sex-matched healthy cases from September 2020 to October 2021. Results; a significant change was found among positive and negative inhibitors regarding the number of factors eight exposure days >20 days (in positive inhibitors was 59.3% compared to adverse inhibitors 27.8%). Conclusion: The (TNF-)308 gene polymorphism is significantly correlated with inhibitor progress in severe Haemophilia A cases. TNF-Alpha gene might be of use as a biomarker as well possible immune response modulator in Haemophilia A patients receiving substitute treatment. Keywords: polymorphism, TNF-α -308Haemophilia, inhibitor, prophylaxis - intracranial hemorrhage and pediatrics.

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Cytokine gene polymorphisms in Asian Indian patients with Takayasu’s Arteritis (TA) – a single center study

Cited by 2 publications

References 0 publications

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis

Tumor necrosis factor (TNF)-α-308 gene polymorphism in children of Haemophilia A

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