Cytokine gene expression in primary brain tumours, metastases and meningiomas suggests specific transcription patterns

Merlo, Adrian; António, José; Filgueira, Luis; Lüscher, Urs; Caetano, Verena; Ulrich, J.; Gratzl, O.; Heberer, Michael; Spagnoli, Giulio C.

doi:10.1016/0959-8049(93)90046-i

Cited by 44 publications

(32 citation statements)

References 24 publications

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“…Unexpectedly, despite the presence of similar inducers, GM-CSF was not detected in vivo, perhaps due to its suppression by tumor-derived inhibitory factors (Frei et al, 1992b;Merlo et al, 1993). The accumulation of macrophages in tumors might be due instead to the synthesis of other chemoattractant factors, such as macrophage chemoattractant protein-1 (MCP-1).…”

Section: Granulocyte/macrophage Colony-stimulating Factormentioning

confidence: 99%

Cytokines and tumors of the central nervous system

Meir¹

1995

Glia

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Cytokines are a group of molecules with an extremely broad range of activities on a variety of target cells. This review summarizes the known cytokine and cytokine receptor expression in primary brain tumors and derived cell lines. These expression patterns are compared with those occurring in other CNS diseases, such as virus or bacterial infections, experimental allergic encephalitis, multiple sclerosis, and trauma. A variety of cytokines are expressed during CNS neoplasia; their potential involvement in tumor growth through a variety of mechanisms, such as autocrine or paracrine growth stimulation, angiogenesis, and immune surveillance evasion, are discussed. Finally, results of preliminary therapeutic approaches with cytokines are critically evaluated.

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Section: Granulocyte/macrophage Colony-stimulating Factormentioning

confidence: 99%

Cytokines and tumors of the central nervous system

Meir¹

1995

Glia

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“…In this context, a number of studies from different groups, including ours, have reported the expression of cytokine genes in neoplastic tissues, including ovarian cancers (Pisa et al, 1992), renal cell carcinomas , brain tumors (Bodmer et al, 1989;Merlo et al, 1993) and melanoma (Lüscher et al, 1994). In some instances, an immunosuppressive role of cytokines actually produced by tumor cells has been suggested (Bodmer et al, 1989).…”

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confidence: 91%

GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens

Trutmann¹,

Terracciano²,

Noppen³

et al. 1998

Int. J. Cancer

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“…Selective expression of cytokines by TILs has been reported in melanoma, ovarian and brain tumours (Pisa et al, 1992; Merlo et al, 1993;Luscher et al, 1994). The local production of cytokines by TILs within the tumour microenvironment is crucial in mounting an immune response to tumour cells, and the presence of suppressive cytokines might thwart the effector response.…”

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confidence: 99%

High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours

Venetsanakos

Beckman²,

Bradley³

et al. 1997

Br J Cancer

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Summary Despite the presence of a lymphocytic infiltrate in solid cancers, the failure for tumour growth to be contained suggests an inadequate immune response to the tumour. Poor cytotoxicity exerted by tumour-infiltrating lymphocytes (TILs) against tumour cells in vitro, combined with continued tumour growth in vivo, suggests deficiencies in TIL function or numbers. Various theories have been postulated to explain how tumour cells may escape immunosurveillance and control. One of the many hypotheses is the failure of production of cytokines, which are necessary for T cells to mediate their function. Thus, the expression of cytokine mRNA in human breast tumour sections was investigated by reverse transcriptase polymerase chain reaction (RT-PCR) with cytokine-specific primers. A relatively consistent finding was detection of interleukin (IL) 10 mRNA among the tumours. No IL-2 and little IL-4 mRNA was detected in the tumours. IL-6 and IL-10 mRNA was detected in only one and two of the normal breast tissues respectively. IL-2, IL-4 and tumour necrosis factor (TNF)-a mRNA was not detected in any of the normal breast tissues. The reduced function of TILs may be related to IL-10, which has known inhibitory effects on T-cell activation.

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Cytokine gene expression in primary brain tumours, metastases and meningiomas suggests specific transcription patterns

Cited by 44 publications

References 24 publications

Cytokines and tumors of the central nervous system

Cytokines and tumors of the central nervous system

GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens

High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours

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