Cytokine gene expression in intestinal tuberculosis and Crohn's disease

Pugazhendhi, Srinivasan; Jayakanthan, K.; Ab, Pulimood; Ramakrishna, B. S.

doi:10.5588/ijtld.12.0600

Cited by 9 publications

(9 citation statements)

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“…Decreased IL-6 expression may highlight its protective role in PTB patients. Low IL-6 production was observed in DM patients similar to Brazilian study; its elevation was reported in human adipocyte supernatants of both humans and Rabbits in USA and in individuals with Crohn's disease [39][40][41]. The CC genotype was considered as the high producer genotype in the PTB patients which was distinct from a study where IL-6 levels did not differ significantly between the -174G>C genotypes in the PTB patients and the HCs [42].…”

Section: Discussionsupporting

confidence: 52%

Diverse Pattern of Cytokine Production, their Functional Association and mRNA Expression in Tuberculosis Patients with Diabetes Mellitus and their Household Contacts

Ponnana¹,

Ramya²,

A³

et al. 2017

J Microb Biochem Technol

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Section: Discussionsupporting

confidence: 52%

Diverse Pattern of Cytokine Production, their Functional Association and mRNA Expression in Tuberculosis Patients with Diabetes Mellitus and their Household Contacts

Ponnana¹,

Ramya²,

A³

et al. 2017

J Microb Biochem Technol

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“…The first community (Cluster 1—red) of non-cancer lung diseases contained COPD, sarcoidosis (SARC), and tubercolosis (TB). Numerous experimental studies, including our own, implicated immune/inflammatory pathways such as Toll-like receptor signaling, phagocytosis, and chemokine signaling in sarcoidosis, tuberculosis, and COPD (Arakelyan et al, 2009 ; Haspel and Choi, 2011 ; Kriegova et al, 2011 ; An et al, 2012 ; Maertzdorf et al, 2012 ; Pabst et al, 2013 ; Pugazhendhi et al, 2013 ). Moreover, differential gene expression as well as gene polymorphisms associated with these diseases demonstrated considerable mutual overlap (Arakelyan et al, 2009 ; Haspel and Choi, 2011 ).…”

Section: Resultsmentioning

confidence: 91%

Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases

et al. 2016

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Lung diseases are described by a wide variety of developmental mechanisms and clinical manifestations. Accurate classification and diagnosis of lung diseases are the bases for development of effective treatments. While extensive studies are conducted toward characterization of various lung diseases at molecular level, no systematic approach has been developed so far. Here we have applied a methodology for pathway-centered mining of high throughput gene expression data to describe a wide range of lung diseases in the light of shared and specific pathway activity profiles. We have applied an algorithm combining a Pathway Signal Flow (PSF) algorithm for estimation of pathway activity deregulation states in lung diseases and malignancies, and a Self Organizing Maps algorithm for classification and clustering of the pathway activity profiles. The analysis results allowed clearly distinguish between cancer and non-cancer lung diseases. Lung cancers were characterized by pathways implicated in cell proliferation, metabolism, while non-malignant lung diseases were characterized by deregulations in pathways involved in immune/inflammatory response and fibrotic tissue remodeling. In contrast to lung malignancies, chronic lung diseases had relatively heterogeneous pathway deregulation profiles. We identified three groups of interstitial lung diseases and showed that the development of characteristic pathological processes, such as fibrosis, can be initiated by deregulations in different signaling pathways. In conclusion, this paper describes the pathobiology of lung diseases from systems viewpoint using pathway centered high-dimensional data mining approach. Our results contribute largely to current understanding of pathological events in lung cancers and non-malignant lung diseases. Moreover, this paper provides new insight into molecular mechanisms of a number of interstitial lung diseases that have been studied to a lesser extent.

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“…This underscores the practical difficulty of differentiating the two in community setting where experts and advanced diagnostic facilities are not widely available. A recent attempt at ultrastructural and molecular differentiation can be seen e.g ., (1) claudin 2 expressed in the upper part of intercellular junction with maintained tight junction in ITB compared to CD where it is increased along the whole length of intercellular junction[ 102 ]; (2) mesenchymal cell marker CD73 being expressed only in ITB granuloma but not CD granuloma[ 103 ]; and (3) increased expression of growth related oncogene alpha mRNA in biopsy specimen and of IL17 in peripheral blood mononuclear cells of ITB cases compared to CD whereas increased IL 1, IL 6 and IL 8 in peripheral blood mononuclear cells and increased gamma interferon, TLR 5 and 9 and decreased RANTES in biopsy specimen of CD cases compared to ITB[ 104 ].…”

Section: Differentiation Of CD From Itbmentioning

confidence: 99%

Inflammatory bowel disease in India - Past, present and future

Ray¹

2016

WJG

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There is rising incidence and prevalence of inflammatory bowel disease (IBD) in India topping the Southeast Asian (SEA) countries. The common genes implicated in disease pathogenesis in the West are not causal in Indian patients and the role of “hygiene hypothesis” is unclear. There appears to be a North-South divide with more ulcerative colitis (UC) in north and Crohn’s disease (CD) in south India. IBD in second generation Indian migrants to the West takes the early onset and more severe form of the West whereas it retains the nature of its country of origin in migrants to SEA countries. The clinical presentation is much like other SEA countries (similar age and sex profile, low positive family history and effect of smoking, roughly similar disease location, use of aminosalicylates for CD, low use of biologics and similar surgical rates) with some differences (higher incidence of inflammatory CD, lower perianal disease, higher use of aminosalicylates and azathioprine and lower current use of corticosteroids). UC presents more with extensive disease not paralleled in severity clinically or histologically, follows benign course with easy medical control and low incidence of fulminant disease, cancer, complications, and surgery. UC related colorectal cancer develop in an unpredictable manner with respect to disease duration and site questioning the validity of strict screening protocol. About a third of CD patients get antituberculosis drugs and a significant number presents with small intestinal bleed which is predominantly afflicted by aggressive inflammation. Biomarkers have inadequate diagnostic sensitivity and specificity for both. Pediatric IBD tends to be more severe than adult. Population based studies are needed to address the lacunae in epidemiology and definition of etiological factors. Newer biomarkers and advanced diagnostic techniques (in the field of gastrointestinal endoscopy, molecular pathology and genetics) needs to be developed for proper disease definition and treatment.

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Cytokine gene expression in intestinal tuberculosis and Crohn's disease

Abstract: Cytokine gene expression patterns in intestinal mucosa and PBMC of intestinal TB were remarkably similar to Crohn's disease, and demonstrated innate immune activation and T-helper 1 polarisation.

Cited by 9 publications

References 0 publications

Diverse Pattern of Cytokine Production, their Functional Association and mRNA Expression in Tuberculosis Patients with Diabetes Mellitus and their Household Contacts

Diverse Pattern of Cytokine Production, their Functional Association and mRNA Expression in Tuberculosis Patients with Diabetes Mellitus and their Household Contacts

Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases

Inflammatory bowel disease in India - Past, present and future

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