Cytokine expression in response to root repair agents

Oliveira, Ricardo Reis; Tavares, Warley Luciano Fonseca; Reis, Andressa Lamari; Silva, V. A.; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1111/iej.12944

Cited by 8 publications

(3 citation statements)

References 45 publications

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“…IL6 is a pleiotropic cytokine playing an active role in immune responses and in the development of the acute phase response (Heinrich et al, 1990). In vivo , the increased secretion of IL6 promotes monocyte differentiation into mobile and active macrophages able to secrete MCP1 and Metalloproteinases (MMPs), facilitating the invasion from the adventitia into the media (Kagan and Medzhitov, 2006) and it is also involved in root repair (Oliveira et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA)

et al. 2019

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Curcumin, primary component of the spice turmeric extracted from the rhizomes of Curcuma longa , represents the major anti-oxidant and anti-inflammatory substance found in turmeric, acting thought various mechanisms not completely understood. Curcumin modulates cytokines, growth factors, transcription factors, inflammatory molecules and cell signaling pathways. During restorative dentistry practice, free resin monomers of 2-hydroxyethyl methacrylate (HEMA) propagate through dentin micro-channel and pulp into the bloodstream affecting cellular integrity. The study highlights the significance of application of curcumin bioactive component into liposomal formulations (CurLIP) to restore the homeostasis of dental pulp stem cells (hDPSCs) in response to 3 and 5 mmol L –1 HEMA treatment. Cell proliferation in combination with changes of the morphological features, proinflammatory cytokines secretion as Interleukin (IL) 6, IL8, Monocyte Chemoattractant Protein-1 (MCP1) and Interferon-gamma (IFNγ) were assayed along with the nuclear factor (NF)-kB, an inducible transcription factor involved in the activation of several cell processes associated to extracellular signal-regulated kinases (ERK) and posphorylated (p-) ERK pathway. Our results showed a decreased cell proliferation, morphological changes and upregulation of IL6, IL8, MCP1 and IFNγ in presence of 3 and 5 mmol L –1 HEMA treatment. CurLIP therapy in hDPSCs provokes an increase in cell proliferation and the block of inflammatory cytokines secretion through the inhibitory regulation of NFkB/ERK and pERK signaling cascade. The natural nanocarrier CurLIP influences numerous biochemical and molecular cascades causing anti-inflammatory properties in response to HEMA treatment in human dental pulp stem cells, representing an innovative endodontic formulation able to improve the quality of dental care with a major human community impact.

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Section: Discussionmentioning

confidence: 99%

Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA)

et al. 2019

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“…Está indicado para restauraciones de lesiones subgingivales y subóseas. Los estudios describen una mayor capacidad de sellado al ser comparada con MTA en ambientes con presencia de saliva y sangre ( [16][17][18] ).…”

Section: Discussionunclassified

Reabsorción cervical externa por filtración de un material aclarante

Ventura

Gutiérrez

Iberico

et al. 2020

Rev Cient Odontol (Lima)

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La reabsorción cervical externa es un proceso patológico con una etiología no comprendida en su totalidad. Los posibles factores predisponentes son el tratamiento de ortodoncia, los traumatismos, el blanqueamiento interno, el bruxismo, entre otros. El blanqueamiento interno es una forma efectiva y mínimamente invasiva de blanquear dientes no vitales, con un riesgo asociado con reabsorción, que al no ser tratado podría provocar incluso la pérdida dentaria. Este reporte de caso describe el manejo de dos incisivos superiores con reabsorciones cervicales externas, que tienen como antecedente tratamiento de conducto y blanqueamiento interno.

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“…We countered this drawback, by covering it with a high-sealing, periodontally compatible restorative material, which will also promote tissue attachment and maintain the proper root contour [7]. Geristore® even showed advantageous properties at inflammatory cytokine expression levels [8]. The advantages of 3 Case Reports in Dentistry amalgam over resin-bonded restorations include the ease of manipulation, good seal, and lower cost.…”

Section: Discussionmentioning

confidence: 99%

Five-Year Recall after Treatment of External Cervical Resorption

Aljarbou

2019

Case Reports in Dentistry

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The management of external cervical resorption can be challenging. This study described a two-step procedure for the treatment of external cervical resorption. It involved nonsurgical root canal treatment and a dental amalgam core buildup, followed by a surgical approach to restore the root structure using resin-modified glass ionomer (Geristore®). The patient was recalled for a period of five years, and the overall outcome was successful.

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Cytokine expression in response to root repair agents

Abstract: The clinical indication of these repair agents depends on the root resorption diagnosis. Whilst MTA and Emdogain induce a pro- and anti-inflammatory response early and late, respectively, Geristore was not associated with an inflammatory reaction when compared with both repair agents.

Cited by 8 publications

References 45 publications

Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA)

Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA)

Reabsorción cervical externa por filtración de un material aclarante

Five-Year Recall after Treatment of External Cervical Resorption

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