Cytokine Expression and Production Changes in Very Old Age

McNerlan, Susan E.; Ross, Owen A.; Rea, Irene Maeve

doi:10.1007/978-3-319-64597-1_40-1

Cited by 4 publications

(3 citation statements)

References 149 publications

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“…Cytokine genes control cytokines, which in turn drive the immune response (McNerlan et al 2009 ). Together they orchestrate and maintain the immune system thorough out life and seem likely to have an important role in good quality ageing and longevity.…”

Section: Good Health and Immunitymentioning

confidence: 99%

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

et al. 2015

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Understanding how to ‘Age Longer and Age Well’ is a priority for people personally, for populations globally and for government policy. Nonagenarians are the oldest members of our societies and survivors of their generation. Approximately 10 % of nonagenarians reach 90 years and beyond in good condition and seem to have a combination of both age-span and health-span. But what are the factors which help people reach their ninetieth birthday and beyond in good condition? Are they genetics, as in ‘nature’, or do they depend on ‘nurture’ and are related to environment, or are both factors inextricably intertwined within the concept of behavioural genetics? Nonagenarians have rich life experiences that can teach us much about ageing well; they are reservoirs of genetic, life-style and behavioural information which can help dissect out how to live not only longer but better. Personal family history and narrative are powerful tools that help to determine familial traits, beliefs and social behaviours and when used in parallel with new biotechnology methods inform and elaborate causality. Here we present themes and insights from personal narrative enquiry from nonagenarian participants from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST) about factors they consider important for good quality ageing and relate these insights to the emerging genetics and life-style evidence associated with healthy longevity.

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Section: Good Health and Immunitymentioning

confidence: 99%

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

et al. 2015

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“…The immune system is susceptible to age-related changes [ 4 ]. Alterations in lymphocyte subsets and cytokine dysregulation play vital roles in the inability to control systemic inflammation and seem to be markers of unsuccessful aging [ 11 , 12 , 13 ]. The causes of “inflamm-aging” are not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

AMPK Amplifies IL2–STAT5 Signaling to Maintain Stability of Regulatory T Cells in Aged Mice

Pokhrel

Kang

Timilshina

et al. 2022

IJMS

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AMP-activated protein kinase (AMPK), an important regulator of the aging process, is expressed in various immune cells. However, its role in regulatory T cell (Treg) stability during aging is poorly understood. Here, we addressed the role of AMPK in Treg function and stability during aging by generating Treg-specific AMPKα1 knockout mice. In this study, we found that AMPKα1-deficient Tregs failed to control inflammation as effectively as normal Tregs did during aging. AMPK knockout from Tregs reduces STAT5 phosphorylation in response to interleukin (IL)-2 stimulation, thereby destabilizing Tregs by decreasing CD25 expression. Thus, our study addressed the role of AMPK in Tregs in sensing IL-2 signaling to amplify STAT5 phosphorylation, which, in turn, supports Treg stability by maintaining CD25 expression and controlling inflamm-aging.

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“…However, it is conceivable that in older adults who might exhibit lower basal levels of IL-2 or IFN-alfa, or might have an impaired capacity to produce these cytokines (239,240), these individuals might exhibit a greater risk of cancer and poorer anti-tumor responses. Indeed, the shift to a proinflammatory phenotype is well-known with aging (241) and some evidence shows this profile is reversed in extremely old populations, termed 'anti-inflammaging' (242,243).…”

Section: Aging Influences Tumor Progression and Cancer Outcomesmentioning

confidence: 99%

A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling

et al. 2021

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Breast cancer is the most common malignancy among women worldwide. Over the last four decades, diagnostic and therapeutic procedures have improved substantially, giving patients with localized disease a better chance of cure, and those with more advanced cancer, longer periods of disease control and survival. However, understanding and managing heterogeneity in the clinical response exhibited by patients remains a challenge. For some treatments, biomarkers are available to inform therapeutic options, assess pathological response and predict clinical outcomes. Nevertheless, some measurements are not employed universally and lack sensitivity and specificity, which might be influenced by tissue-specific alterations associated with aging and lifestyle. The first part of this article summarizes available and emerging biomarkers for clinical use, such as measurements that can be made in tumor biopsies or blood samples, including so-called liquid biopsies. The second part of this article outlines underappreciated factors that could influence the interpretation of these clinical measurements and affect treatment outcomes. For example, it has been shown that both adiposity and physical activity can modify the characteristics of tumors and surrounding tissues. In addition, evidence shows that inflammaging and immunosenescence interact with treatment and clinical outcomes and could be considered prognostic and predictive factors independently. In summary, changes to blood and tissues that reflect aging and patient characteristics, including lifestyle, are not commonly considered clinically or in research, either for practical reasons or because the supporting evidence base is developing. Thus, an aim of this article is to encourage an integrative phenomic approach in oncology research and clinical management.

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Cytokine Expression and Production Changes in Very Old Age

Cited by 4 publications

References 149 publications

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

AMPK Amplifies IL2–STAT5 Signaling to Maintain Stability of Regulatory T Cells in Aged Mice

A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling

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