2014
DOI: 10.1111/jvim.12388
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Cytokine Concentrations in the Cerebrospinal Fluid of Great Danes with Cervical Spondylomyelopathy

Abstract: BackgroundChronic inflammation is involved in the pathogenesis of human cervical spondylotic myelopathy and could also play a role in cervical spondylomyelopathy (CSM) in dogs.Hypothesis/ObjectivesThat cerebrospinal fluid (CSF) cytokine concentrations would differ between clinically normal (control) and CSM‐affected Great Danes (GDs), with affected GDs showing higher levels of inflammatory cytokines, such as interleukin (IL)‐6 and monocyte chemoattractant protein‐1/chemokine ligand 2 (MCP‐1/CCL2).AnimalsClient… Show more

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Cited by 7 publications
(14 citation statements)
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“…Cerebrospinal fluid samples were prospectively collected as part of a different study, and remaining CSF was banked for prospective evaluation of the miRNA expression profile of Great Danes. The study was conducted in accordance with the guidelines and with approval of the institution's Clinical Research Advisory Committee and the Institutional Animal Care and Use Committee.…”
Section: Methodsmentioning
confidence: 99%
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“…Cerebrospinal fluid samples were prospectively collected as part of a different study, and remaining CSF was banked for prospective evaluation of the miRNA expression profile of Great Danes. The study was conducted in accordance with the guidelines and with approval of the institution's Clinical Research Advisory Committee and the Institutional Animal Care and Use Committee.…”
Section: Methodsmentioning
confidence: 99%
“…The OA‐CSM affected dogs were identified and included in the study if they exhibited clinical signs and neurological examination findings consistent with a diagnosis of cervical myelopathy. All dogs included in the study underwent standardized gait grading, cerebellomedullary cistern CSF collection, and MRI of the cervical vertebral column. The OA‐CSM was confirmed on MRI by 2 investigators (P.M.V.…”
Section: Methodsmentioning
confidence: 99%
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