Cytokine Biopharmaceuticals with “Activity-on-Demand” for Cancer Therapy
Giulia Rotta,
Emanuele Puca,
Samuele Cazzamalli
et al.
Abstract:Cytokines
are small proteins that modulate the activity of the
immune system. Because of their potent immunomodulatory properties,
some recombinant cytokines have undergone clinical development and
have gained marketing authorization for the therapy of certain forms
of cancer. Recombinant cytokines are typically administered at ultralow
doses, as many of them can cause substantial toxicity even at submilligram
quantities. In an attempt to increase the therapeutic index, fusion
proteins based on tumor-homing an… Show more
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