Cytokine and human leukocyte antigen (HLA) profile for graft-versus-host disease (GVHD) after organ transplantation

Abstract

BackgroundGraft-versus-host disease (GVHD) after liver and kidney transplantation has high mortality and causes diagnostic challenges. This study aims to describe the cytokine and human leukocyte antigen (HLA) profile in the GVHD after liver and kidney transplantation.MethodsA high-throughput detection kit was applied and altogether 18 different cytokines were tested simultaneously. GVHD patients included 23 post-liver transplantation patients; 22 post-renal transplantation patients; The control patients include 22 hepatocellular carcinoma (HCC) patients without transplantation and 20 healthy controls. Their HLA characters were compared.ResultsThe full spectrum of cytokines was present. The inflammatory markers were activated significantly in liver transplantation. The level of inflammatory markers in liver transplantation was higher than that in renal transplantation, HCC or healthy controls. GVHD was associated with the HLA characters; HLA characters are involved in liver GVHD occurrence and act as risk factors.ConclusionOur findings confirmed that the inflammatory cytokines play a pathogenic role in GVHD and can be used as early diagnostic markers. The HLA mismatch acts as a risk factor in liver transplantation to predict GVHD occurrence.Graphical abstractDiagnostic and therapeutic target for GVHD

A porcine model to study the effect of brain death on kidney genomic responses

“…Toll-like receptor-4 (TLR-4) has been increasingly recognized as playing a critical role in the pathogenesis of I:R injury of renal grafts [42, 43], and research into anti-TNF agents have shown promise with regards to being protective against I:R injury in animal models [21]. Additionally, we identified pathways associated with common immunologic processes affecting renal transplantation and rejection, such as graft-versus-host disease [44], natural killer cell-mediated toxicity [45], Jak-STAT signaling [46], peroxisome proliferator-activated receptor signaling [47], chemokine signaling, and allograft rejection.…”

Acute Graft Versus Host Disease Following Liver Transplantation: Case Report With Review of Current Literature

“…Exaggerated cytokine response of IL 2, IL 18, and IFN-g occurs during GVHD have been used to predict the occurrence of GVHD early. 11 Chimerism is the presence of donor lymphocytes in the recipient's peripheral blood, skin, or bone marrow. Donor T cell chimerism peaks around the first week after LT and reduces to <1% by 4 weeks, confirm-ing donor engraftment.…”

Erratum to: Cytokine and human leukocyte antigen (HLA) profile for graft-versus-host disease (GVHD) after organ transplantation

“…Following publication of the original article [ 1 ], the authors requested a correction in the presentation of their institutions as they appear on the Web of Science. Specifically, it should be emphasized that the institutions belong to Zhejiang University.…”