Cytokine and Growth Factor Delivery from Implanted Platelet-Rich Fibrin Enhances Rabbit Achilles Tendon Healing

Wong, Chin-Chean; Huang, Yu‐Min; Chen, Chih-Hwa; Lin, Feng Huei; Yeh, Yi Yen; Bai, Meng Yi

doi:10.3390/ijms21093221

Cited by 24 publications

(17 citation statements)

References 38 publications

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“…Further, gene expression analyses revealed the significant increase in COL1A1 and COL3A1 mRNA expression in the bPRF-treated groups. Corresponding to previous studies, PRF enhanced COL1A1 and COL3A1 mRNA expression in rabbit tenocytes in vitro [37]. Type III collagen is predominant in the proliferative phase of wound healing and is replaced by type I collagen.…”

Section: Discussionsupporting

confidence: 79%

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Evaluation of the Use of Platelet-Rich Fibrin Xenologous Membranes Derived from Bubaline Blood in Canine Periodontal Defects

Banyatworakul

Osathanon

Kalpravidh

et al. 2021

Veterinary Sciences

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Periodontal disease is the most common oral disease in dogs. Platelet-rich fibrin (PRF) is widely utilized to facilitate soft and hard tissue healing and has been proposed in periodontal healing in small animal treatment. However, the quality and amount of autologous PRF is compromised in animals with systemic diseases. The present study aimed to evaluate the efficacy of xenologous bubaline blood-derived PRF (bPRF) on periodontal tissue healing in canine periodontal defects. Split-mouth design was employed in twenty dogs diagnosed with periodontal disease. The defects were divided randomly into two groups: the open-flap debridement (OFD)-treated group and the OFD with bPRF (OFD+bPRF) application group. Results demonstrated that gingival index and periodontal probing depth decreased significantly in the OFD+bPRF group compared with those treated with OFD alone. Application of bPRF in periodontal defects also promoted fibrous tissue formation, as confirmed by the marked increase in fibrosis score. bPRF application significantly increased COL1A1 and PDGFB mRNA levels at day 14 compared with the baseline. Taking this evidence together, bPRF provided a favorable therapeutic modality in canine periodontal defects. bPRF could be an alternative biomaterial for the treatment of periodontal defects in dogs.

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Section: Discussionsupporting

confidence: 79%

“…The role of PRF in soft tissue healing has previously been reported. PRF accelerated epithelialization and lessened scar formation in canine cutaneous incisional wound healing [37]. PRF also stimulated collagen-related protein expression compared with untreated controls [38].…”

Section: Discussionmentioning

confidence: 84%

Evaluation of the Use of Platelet-Rich Fibrin Xenologous Membranes Derived from Bubaline Blood in Canine Periodontal Defects

Banyatworakul

Osathanon

Kalpravidh

et al. 2021

Veterinary Sciences

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“…Research by Kishimoto et al ( 2017 ) reported that activation of Wnt/β-catenin signaling suppressed expressions of tenogenic genes of Scleraxis (Scx), Mohawk (Mkx), and Tenomodulin (Tnmd) in rat tendon–derived cells isolated from the Achilles tendons of 6-week-old rats. All three genes are vital for tendon development, maintenance, and regeneration ( Yang et al, 2019 ; Wong et al, 2020 ; Best et al, 2021 ). This suggests that an inhibition of Wnt/β-catenin signaling may represent a novel therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

A Global Phosphorylation Atlas of Proteins Within Pathological Site of Rotator Cuff Tendinopathy

Wang

Zhang

Lin

et al. 2022

Front. Mol. Biosci.

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Rotator cuff tendinopathy (RCT) is the most common cause of shoulder pain, therefore posing an important clinical problem. Understanding the mechanism and biochemical changes of RCT would be of crucial importance and pave the path to targeting novel and effective therapeutic strategies in translational perspectives and clinical practices. Phosphorylation, as one of the most important and well-studied post-translational modifications, is tightly associated with protein activity and protein functional regulation. Here in this study, we generated a global protein phosphorylation atlas within the pathological site of human RCT patients. By using Tandem Mass Tag (TMT) labeling combined with mass spectrometry, an average of 7,741 phosphorylation sites (p-sites) and 3,026 proteins were identified. Compared with their normal counterparts, 1,668 p-sites in 706 proteins were identified as upregulated, while 73 p-sites in 57 proteins were downregulated. GO enrichment analyses have shown that majority of proteins with upregulated p-sites functioned in neutrophil-mediated immunity whereas downregulated p-sites are mainly involved in muscle development. Furthermore, pathway analysis identified NF-κB–related TNF signaling pathway and protein kinase C alpha type (PKCα)–related Wnt signaling pathway were associated with RCT pathology. At last, a weighted kinase-site phosphorylation network was built to identify potentially core kinase, from which serine/threonine-protein kinase 39 (STLK3) and mammalian STE20-like protein kinase 1 (MST1) were proposed to be positively correlated with the activation of Wnt pathway.

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“…The local application of combined ascorbic acid and T 3 also showed the potential benefits for accelerated tendon healing (Oliva, et al, 2019). Platelet-rich fibrin (PRF), with the delivery of cytokine and growth factor, induced more organized collagen fibers in vivo and promoted tenocyte viability and tenogenic phenotypic differentiation in vitro (Wong, et al, 2020). Similarly, plateletrich plasma (PRP) is widely used and has been proven to be effective for tendon healing in vivo (Chiou, et al, 2015).…”

Section: Strategies For Achilles Tendon Repairmentioning

confidence: 99%

Advances in Regenerative Sports Medicine Research

Wang

Jiang

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Regenerative sports medicine aims to address sports and aging-related conditions in the locomotor system using techniques that induce tissue regeneration. It also involves the treatment of meniscus and ligament injuries in the knee, Achilles’ tendon ruptures, rotator cuff tears, and cartilage and bone defects in various joints, as well as the regeneration of tendon–bone and cartilage–bone interfaces. There has been considerable progress in this field in recent years, resulting in promising steps toward the development of improved treatments as well as the identification of conundrums that require further targeted research. In this review the regeneration techniques currently considered optimal for each area of regenerative sports medicine have been reviewed and the time required for feasible clinical translation has been assessed. This review also provides insights into the direction of future efforts to minimize the gap between basic research and clinical applications.

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Cytokine and Growth Factor Delivery from Implanted Platelet-Rich Fibrin Enhances Rabbit Achilles Tendon Healing

Cited by 24 publications

References 38 publications

Evaluation of the Use of Platelet-Rich Fibrin Xenologous Membranes Derived from Bubaline Blood in Canine Periodontal Defects

Evaluation of the Use of Platelet-Rich Fibrin Xenologous Membranes Derived from Bubaline Blood in Canine Periodontal Defects

A Global Phosphorylation Atlas of Proteins Within Pathological Site of Rotator Cuff Tendinopathy

Advances in Regenerative Sports Medicine Research

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