Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection

Increased Protection from Vaccinia Virus Infection in Mice Genetically Prone to Lymphoproliferative Disorders

“…We will show that this is the case with VACV and will discuss this along with other recent studies supporting this point (8,24,30,31,40,41).…”

“…Other studies demonstrated decreased incidence of HIV associated with a single-nucleotide deletion in FASLnt169 and increased recovery of CD4 ϩ T-cell counts after antiretroviral treatment in HIV-infected individuals bearing specific combinations of polymorphisms in the FAS or FASL genes or promoter regions (40). The FAS-670A/A polymorphism has also been associated with viral clearance in patients with HCV (30). IFN-␥ has been shown to directly inhibit HCV in virus replicon systems, and this mechanism could explain this association (9,14).…”

IL-18 polymorphisms in hepatitis B virus related liver disease

“…In various populations, IL-18 gene promoter polymorphism at either -607 or -137 position, or both has been shown to be associated in many diseases. For example Systemic lupus erythematosus [25], Rheumatoid arthritis [26], Hepatocellular carcinoma [31], Human immunodeficiency virus (HIV) [38], Gastrointestinal cancers [39], and viral infections like Hepatitis C (HCV) [36,37] (Table 6). …”

Análise de polimorfismos, expressão gênica e níveis séricos de IL-18, IL18BP e IFN-y na infecção crônica pelo HCV e resolução espontânea

“…In a previous study, it was demonstrated that the -607A allele occurred more frequently in the clearance group than in chronic infection and the -137C allele was also more frequently observed in the clearance group than in chronic infection, but this difference was just observed in African American and was not observed in European American [61,110].…”

“…However other studies have had a different opinion about this polymorphism and the infection of HCV [61,110].…”