Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis

Howe, Aaron; Lynch, David A.

doi:10.1016/j.bbih.2022.100490

Cited by 4 publications

(3 citation statements)

References 111 publications

(293 reference statements)

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“…60% ≤ I 2 < 90% indicated a considerable degree of heterogeneity, and 90% ≤ I 2 < 100% indicated substantial heterogeneity. 25 We used random-effects or fixed-effects models to summarize data from studies. Subgroup analysis was conducted to investigate possible resources of heterogeneity.…”

Section: Data Combination and Analysismentioning

confidence: 99%

Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients with Asthma: A Systematic Review and Meta-Analysis

Zheng

Sun

et al. 2023

Am J Rhinol�Allergy

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Objective Sublingual immunotherapy (SLIT) has been widely applied to treat patients with allergic rhinitis (AR). However, meta-analyses on the efficacy of SLIT in AR patients with asthma are still limited. Methods Literature without language limitation published before October 28, 2022, were retrieved from PubMed, EMBASE, and Cochrane Library. STATA 16.0 software was used for the meta-analysis of the extracted data. The results reported were symptom scores, drug scores, adverse effects rates, and cost of treatment. Results Ten studies involving 1722 patients met the inclusion criteria. The total rhinitis score (TRSS) (weighted mean difference [WMD] = −1.23, 95% CI: −1.39-−1.06, P < .001) and total asthma symptom score (TASS) (WMD = −1.00, 95% CI: −1.12–0.89, P < .001) were significantly lower in the SLIT group than the placebo group. The SLIT group had higher rates of treatment-related adverse events (relative risk [RR] = 2.82, 95% CI: 1.77-4.48, P < .001) and total costs of treatment (standardized mean difference [SMD] = 0.71, 95% CI: 0.45-0.97, P < .001). There was no significant difference in inhaled corticosteroids (ICS) dose ( P = .195), fractional exhaled nitric oxide (FeNO) ( P = .158), forced expiratory volume in 1 s (FEV1) ( P = .237), and direct costs of treatment ( P = .630) between the SLIT and placebo groups. Conclusion SLIT may be a therapeutic method for improving rhinitis symptoms and asthma symptoms in AR patients with asthma. However, as there was significant heterogeneity in results, more high-quality and well-designed studies are needed in the future to elucidate the efficacy of SLIT.

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Section: Data Combination and Analysismentioning

confidence: 99%

Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients with Asthma: A Systematic Review and Meta-Analysis

Zheng

Sun

et al. 2023

Am J Rhinol�Allergy

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“…For example, in adolescents at risk of developing a depressive episode, only those with higher blood IL-6 levels will develop affective disorder later on ( Miller and Cole, 2012 ). Thus, adolescents presenting with anxiety and depression display higher blood levels not only of pro-inflammatory cytokines like interleukin (IL)-1β, IL-6, and interferon (IFN)-γ but also of anti-inflammatory cytokines such as IL-1 ( Henje Blom et al, 2012 ; Gabbay et al, 2009a , 2009b ; Howe and Lynch, 2022 ). In addition, post mortem studies have found that adolescents deceased by suicide showed over-expression of the pro-inflammatory cytokines IL-1β and tumor necrosis factor (TNF)-α genes in their prefrontal lobe ( Pandey et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort

Herbein,

Barbosa,

Collet

et al. 2024

Brain, Behavior, & Immunity - Health

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“…Lastly, no relationship between IL-1β, IL-2, IL-6, IL-10, IFN-γ, and TNF-α and pediatric internalizing disorders was observed in the meta-analysis by Howe and Lynch. 43 The heterogeneous findings in the relation to depression and inflammation can be influenced by various factors including genetics, medication use, and sex. Thus, further research in this area is needed to reveal the exact depression-linked immune alterations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression

Ferencova¹,

Višňovcová²,

Ondrejka³

et al. 2022

JIR

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Purpose Nowadays, the role of two tightly interconnected systems, the inflammatory response system (IRS) and the compensatory immune response system (CIRS) in depression, is increasingly discussed. Various studies indicate pro-inflammatory activity in adolescent depression; however, there is an almost complete lack of findings about IRS and CIRS balance. Thus, we aimed to assess different IRS and CIRS indices, profiles, and IRS/CIRS ratios in drug-naïve MDD patients at adolescent age, with respect to sex. Patients and Methods One hundred MDD adolescents (40 boys, average age: 15.4±1.2 yrs.) and 60 controls (28 boys, average age: 15.3±1.5 yrs.) were examined. Evaluated parameters were 1. plasma levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), soluble receptor of IL-6 (sIL-6R), soluble receptors of TNF-α (sTNF-R1, sTNF-R2); 2. profiles: IL-6 trans-signaling, M1 macrophage signaling, helper T lymphocytes (Th) 1 profile, regulatory T lymphocytes (Treg)+Th2, allIRS, and allCIRS; 3. IRS vs CIRS activity ratios: TNF-α/TNF-R1, TNF-α/TNF-R2, TNF-α/sTNF-Rs (ie sTNF-R1+sTNF-R2), Th1/Th2, Th1/Treg, Th1/Th2+Treg, M1/Th2, M1/Treg, M1/Treg+Th2, allIRS/allCIRS. Results MDD patients showed increased IL-4, IL-10, TNF-α, sIL-6R, Treg+Th2, allIRS, allCIRS, and TNF-α/sTNF-Rs, and decreased Th1/Th2+Treg. MDD females showed increased IL-10 and TNF-α compared to control females. MDD males showed increased IL-4, IL-10, sIL-6R, Treg+Th2, and TNF-α/TNF-R1 compared to control males. Increased sTNF-R1 was found in MDD males compared to MDD females. Positive correlations were found between CDI score and sIL-6R and IL-10 in the total group and between CDI score and IL-10 in adolescent males. Conclusion Our study for the first time extensively evaluated IRS and CIRS interactions revealing enhanced pro-inflammatory TNF-α signaling and IL-6 trans-signaling in association with increased IL-10- and IL-4-mediated anti-inflammatory activity in first-episode depression at the adolescent age. Moreover, results reflect the sex-specific simultaneous activation of IRS and CIRS pathways in adolescent depression.

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Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis

Cited by 4 publications

References 111 publications

Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients with Asthma: A Systematic Review and Meta-Analysis

Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients with Asthma: A Systematic Review and Meta-Analysis

Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort

Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression

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