Cytokeratin 8/18 monoclonal antibody was dissimilar to anti-cytokeratin CAM 5.2. — A comment on: “Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation, Experimental and Molecular Pathology 90(2): 194–200, April 2011”

Lin, Wea‐Lung; Chen, Fong-Lin; Kuo, Jang-Fang; Lee, Ming‐Yung; Han, Chih-Ping

doi:10.1016/j.yexmp.2011.04.001

Experimental and Molecular Pathology

2011

DOI: 10.1016/j.yexmp.2011.04.001

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Cytokeratin 8/18 monoclonal antibody was dissimilar to anti-cytokeratin CAM 5.2. — A comment on: “Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation, Experimental and Molecular Pathology 90(2): 194–200, April 2011”

Wea‐Lung Lin¹,

Fong-Lin Chen²,

Jang-Fang Kuo³

et al.

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Genetic variations in colorectal cancer risk and clinical outcome

Zhang¹

2014

WJG

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Colorectal cancer (CRC) has an apparent hereditary component, as evidenced by the well-characterized genetic syndromes and family history associated with the increased risk of this disease. However, in a large fraction of CRC cases, no known genetic syndrome or family history can be identified, suggesting the presence of "missing heritability" in CRC etiology. The genome-wide association study (GWAS) platform has led to the identification of multiple replicable common genetic variants associated with CRC risk. These newly discovered genetic variations might account for a portion of the missing heritability. Here, we summarize the recent GWASs related to newly identified genetic variants associated with CRC risk and clinical outcome. The findings from these studies suggest that there is a lack of understanding of the mechanism of many single nucleotide polymorphisms (SNPs) that are associated with CRC. In addition, the utility of SNPs as prognostic markers of CRC in clinical settings remains to be further assessed. Finally, the currently validated SNPs explain only a small fraction of total heritability in complex-trait diseases like CRC. Thus, the "missing heritability" still needs to be explored further. Future epidemiological and functional investigations of these variants will add to our understanding of CRC pathogenesis, and may ultimately lead to individualized strategies for prevention and treatment of CRC.

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Genetic variations in colorectal cancer risk and clinical outcome

Zhang¹

2014

WJG

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Cited by 1 publication

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Genetic variations in colorectal cancer risk and clinical outcome

Genetic variations in colorectal cancer risk and clinical outcome

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