Cytohistopathologic hybrid renal cell carcinoma with papillary and clear cell features

Kien, T.; Kohler, Derek M.; Delatour, Nicolas LD Roustan; Veinot, John P.

doi:10.1016/j.prp.2006.08.007

Cited by 9 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemically, most CRCC have demonstrated negative immunoreactivity for cytokeratin 7 (CK7) and alpha-methylacyl-coenzyme A racemase (AMACR) in while most PRCC displayed positive immunoreactivity for these antisera [21][22][23][24][25]. In a previous study at our institution, it was demonstrated that there is a group of RCC displaying hybrid cytomorphological and immunohistochemical properties with areas displaying features of CRCC or PRCC, respectively [26].…”

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma with mixed features of papillary and clear cell cytomorphology: a fluorescent in situ hybridization study

et al. 2009

Self Cite

View full text Add to dashboard Cite

We performed fluorescent in situ hybridization (FISH) to investigate the numeric change of chromosomes 7, 17, and Y and loss of chromosome 3p in "papillary renal cell carcinomas (RCC) with extensive clear cell changes (CCC)." Consecutive cases of RCC over a 12-year period were reviewed to identify "papillary RCC with extensive CCC." Immunostaining for cytokeratin 7 and alpha-methylacyl-CoA racemase (AMACR) and FISH for chromosomes 7, 17, Y, and 3p were applied. Of the total of 521 RCC retrieved, there were 49 RCC with papillary architecture and clear cell areas that could be divided into: Group 1 (12 cases), typical clear cell RCC with focal areas of papillary formation; Group 2 (28 cases), focal typical papillary RCC having papillary architecture with extensive CCC; and Group 3 (nine cases), RCC with an admixture of eosinophilic/clear cytoplasm and solid/papillary architecture. Group 1 showed negative immunoreactivity for CK7 and AMACR and absence of numeric chromosomal gain or loss of chromosomes 7/17 and Y. Groups 2 and 3 showed variable reactivity for CK7 and AMACR. Tumors in group 2 and five in group 3 showed trisomies of chromosomes 7 and/or 17 with or without loss of chromosome Y. Loss of small arm 3p was observed in groups 1 and 3 but not in group 2 tumors. In conclusion, papillary RCC may show phenotypical CCC mimicking clear cell RCC. In a small number of cases with mixed histopathological features, FISH is helpful in subtyping RCC.

show abstract

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma with mixed features of papillary and clear cell cytomorphology: a fluorescent in situ hybridization study

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…The observation of a signifi cantly greater proportion of hybrid clear and papillary tumours in group A is an interesting one, in view of preliminary evidence suggesting that these cases have a higher risk of lymph node and distant metastasis. 16 Although histological subtype was not found be a statistically signifi cant prognostic factor in multivariate analysis, this may have been limited by small case numbers of hybrid pathology cases. The higher incidence of non-RCC related mortalities in the group B may have also exerted some infl uence on the overall survival assessment in this study.…”

Section: Discussionmentioning

confidence: 94%

Renal Cell Carcinoma in Young Patients is Associated with Poorer Prognosis

Lee

Yuen

Sim

2011

Ann Acad Med Singap

View full text Add to dashboard Cite

Introduction: Renal cell carcinoma (RCC) in young patients is uncommon but thought to represent a distinctive clinical entity from older patients with different clinico-pathologic features and outcomes. We evaluated the association of age at the time of diagnosis with pathological staging, histological parameters, disease recurrence and overall survival (OS) following radical or partial nephrectomy for non-metastatic RCC in native kidneys. Materials and Methods: A retrospective review of 316 patients with RCC after nephrectomy at a single institution between January 2001 and June 2008 was performed. Eligible patients included all histologically proven primary non-metastatic RCC treated by radical or partial nephrectomy. They were categorised into group A (≤40 years at diagnosis) and B (>40 years). Differences in clinical parameters were analysed using the Mann Whitney U test. The prognostic potential of age at diagnosis was evaluated using Cox proportional hazards regression. Survival was estimated using the Kaplan Meier method. Results: There were 33 patients in group A and 283 patients in group B. There were more non-clear cell tumours in the younger group (30% vs 14%, P <0.05). No statistical differences were found in the stage and grade of both groups. At a median follow-up time of 41 months, the younger group had a higher metastatic rate (18% vs 10.5%, P <0.05), lower 5-year cancer-specific survival (82% vs 98%, P <0.05) and lower 5-year OS (82 % vs 95%, P<0.05). Conclusion: Younger patients were more likely to have non-clear cell RCC with higher disease recurrence and lower OS. They should not be assumed to have similar features and outcomes as screen-detected early RCC in older patients. Key words: Age, Cancer recurrence, Overall survival, Renal cell carcinoma, Nephrectomy

show abstract

“…Some consider these tumors to have a good prognosis, which goes along with their low nuclear grade. Others, however, have shown that a clear cell component is associated with a higher stage (3)(4)(5).…”

Section: Editorial Commentmentioning

confidence: 99%

Pathology

Billis

2008

Int. braz j urol.

View full text Add to dashboard Cite

Cytohistopathologic hybrid renal cell carcinoma with papillary and clear cell features

Cited by 9 publications

References 21 publications

Renal cell carcinoma with mixed features of papillary and clear cell cytomorphology: a fluorescent in situ hybridization study

Renal cell carcinoma with mixed features of papillary and clear cell cytomorphology: a fluorescent in situ hybridization study

Renal Cell Carcinoma in Young Patients is Associated with Poorer Prognosis

Pathology

Contact Info

Product

Resources

About