Cytoglobosins A−G, Cytochalasans from a Marine-Derived Endophytic Fungus, <i>Chaetomium globosum</i> QEN-14

Cui, Chuan‐Ming; Li, Xiaoming; Li, Chun‐Shun; Proksch, Peter; Wang, Bin‐Gui

doi:10.1021/np900569t

Cited by 136 publications

(126 citation statements)

References 16 publications

(76 reference statements)

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“…By recording the change in fluorescence intensity, we measured the rate of polymerization. Cytochalasin D is a well-established mycotoxin that reversibly binds with globular actin monomers to prevent polymerization (44,45). As expected, cytochalasin D inhibited the rate of linear and branched actin polymerization (Fig.…”

Section: Tbe-31 Inhibits Actin Polymerization and Cell Migration Wwwsupporting

confidence: 65%

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

Chan

Saito²,

Honda

et al. 2014

Cancer Prevention Research

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The migratory and invasive potential of the epithelial-derived tumor cells depends on epithelial-tomesenchymal transition (EMT) as well as the reorganization of the cell cytoskeleton. Here, we show that the tricyclic compound acetylenic tricyclic bis(cyano enone), TBE-31, directly binds to actin and inhibits linear and branched actin polymerization in vitro. Furthermore, we observed that TBE-31 inhibits stress fiber formation in fibroblasts as well as in non-small cell lung cancer cells during TGFb-dependent EMT. Interestingly, TBE-31 does not interfere with TGFb-dependent signaling or changes in E-cadherin and Ncadherin protein levels during EMT. Finally, we observed that TBE-31 inhibits fibroblast and non-small cell lung tumor cell migration with an IC 50 of 1.0 and 2.5 mmol/L, respectively. Taken together, our results suggest that TBE-31 targets linear actin polymerization to alter cell morphology and inhibit cell migration. Cancer Prev Res; 7(7); 727-37. Ó2014 AACR.

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Section: Tbe-31 Inhibits Actin Polymerization and Cell Migration Wwwsupporting

confidence: 65%

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

Chan

Saito²,

Honda

et al. 2014

Cancer Prevention Research

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“…Except for 323, cytochalasans were assayed for cytotoxicity against P388 cells, and 310-312 with ED 50 values ranging from 0.6 to 1.0 μM are more active than 313-317 with ED 50 values ranging from 3.4 to 6.3 μM Iwamoto et al 2001). Despite inactivity toward P388 cells, 320 and 321 showed inhibition of A549 cells with IC 50 values of 2.26 and 2.55 μM, respectively (Cui et al 2010a).…”

Section: Alkaloidsmentioning

confidence: 99%

Mycochemistry of marine algicolous fungi

Wang

2016

Fungal Diversity

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Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae, which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity during the past two decades. Up to the end of 2014, a total of 366 new natural products, including polyketides, terpenoids, polyketide-terpenoids, peptides, alkaloids, and shikimate derivatives, have been characterized from them. Among these metabolites, 240 compounds feature cytotoxic, antibacterial, antifungal, antimicroalgal, zooplankton-toxic, antiprotozoal, antioxidative, enzyme-modulatory, and/or some other activities. This review gives a comprehensive coverage of both chemical and biological aspects of the secondary metabolites from marine algicolous fungi.

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“…It is interesting that the three different strains also produced quite different families of antitumor compounds, i.e., benzaldehyde derivatives, cytochalasans and azaphilones [31][32][33][34].…”

Section: Relationship Between Systematics and Biological Potentialmentioning

confidence: 99%

Biological and chemical diversity of cytotoxin-producing symbiotic marine fungi in intertidal zone of Dalian

Zhang

Feng

et al. 2012

Chin. Sci. Bull.

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In this study, the biological and chemical diversity of 8 symbiotic marine fungal strains, with strong cytotoxicity against brine shrimp larvae, were investigated by nucleotide sequencing, morphology and cluster analysis of HPTLC fingerprint. These strains were identified by ITS rDNA sequencing, phylogenic analysis, and morphology to be Hypocrea lixii, Chaetomium globosum, Aspergillus fumigatus, Asp. clavatus and Alternaria sp. Their differences in secondary metabolites were shown by cluster analysis of digitalized colors of HPTLC spots, a newly developed method, which produced a similar dendrogram with that of ITS cluster analysis. Furthermore, this method can fully display intraspecific differences and even the remarkable difference in Aspergillus strains which goes beyond the boundary between genera. Their biological-chemical diversity may be the basis of their potent cytotoxicity and implies their potential in producing diversified antitumor or pesticidal constituents. Symbiotic fungi live on the surface or in the inner tissue of their hosts. Some terrestrial symbiotic fungi have been found to produce toxins or anti-feedants to protect their hosts from predators and grazers [1]. Some of these compounds can be used as antitumor or pesticidal agents. Symbiotic marine fungi have been isolated from seaweeds, sponges, corals, mangroves and sea grasses, also showing taxonomicall diversity and producing numerous active compounds [2]. The intertidal coastline of Dalian possesses diversified natural and artificial habitats and also high biodiversity of marine plants, invertebrates, and microorganisms. In our screening for useful cytotoxins from local symbiotic marine fungi using brine shrimp lethality test, a widely used bifunctional preliminary screening model to discover antitumor drugs and pesticides from the sea [3][4][5], eight strains with potent activities were discovered. Herein, we report the study on the biological and chemical diversity of these bioactive strains by ITS rDNA sequence analysis, morphology, and metabolite fingerprinting using a new cluster method.

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Cytoglobosins A−G, Cytochalasans from a Marine-Derived Endophytic Fungus, Chaetomium globosum QEN-14

Cited by 136 publications

References 16 publications

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

Mycochemistry of marine algicolous fungi

Biological and chemical diversity of cytotoxin-producing symbiotic marine fungi in intertidal zone of Dalian

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