Abstract:Chromosome and array comparative genomic hybridization (aCGH) analyses were performed on two cases of well-differentiated liposarcoma (WDLPS) and two cases of dedifferentiated liposarcoma (DDLPS). The results revealed the characteristic giant ring (GR) or giant rod marker (GRM) chromosomes in all four cases and amplification of numerous somatic copy number alterations (SCNAs) involving a core segment of 12q14.1q15 and other chromosomal regions in three cases. The levels of amplification for oncogenes OS9, CDK4… Show more
“…Besides, RCs as acquired chromosomal abnormalities in human neoplasia such as giant RCs in liposarcoma have also been seen, which are reviewed elsewhere. 121 , 122 …”
Section: Current Understanding Of Constitutional Rcsmentioning
“…Besides, RCs as acquired chromosomal abnormalities in human neoplasia such as giant RCs in liposarcoma have also been seen, which are reviewed elsewhere. 121 , 122 …”
Section: Current Understanding Of Constitutional Rcsmentioning
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