Cytogenetics of six follicular thyroid adenomas including a case report of an oxyphil variant with t(8;14)(q13;q24.1)

Herrmann, Marie A.; Hay, Ian; Bartelt, Duane; Spurbeck, Jack L.; Dahl, Richard J.; Grant, Clive S.; Jenkins, Robert B.

doi:10.1016/0165-4608(91)90175-t

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…Loss of heterozygous alleles on chromosomes 16p and 17p was observed in one FTC (patient 46). LOH of chromosome 10 loci was observed in Genetics ofThyroid Cancer Cytogenetic studies of at least 152 nonmedullary thyroid neoplasms have been reported (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Approximately 50% of the 61 nonmedullary thyroid carcinomas had an abnormal karyotype, while in our present study of 31 thyroid cancers 9 (28%) had clonal abnormalities.…”

Section: Methodsmentioning

confidence: 99%

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Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

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Section: Methodsmentioning

confidence: 99%

“…genetic analyses of these tumors have been reported (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). A preliminary study of 12 thyroid carcinomas from our group (6) demonstrated abnormalities ofchromosomes 3 and 10 in FTC and PTC, respectively.…”

mentioning

confidence: 99%

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

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Cytogenetic studies on 19 papillary thyroid carcinomas

Antonini

Venuat

Caillou

et al. 1992

Genes Chromosomes & Cancer

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Short-term cultures from 19 papillary thyroid adenocarcinomas revealed clonal numerical and/or structural chromosomal changes in 13 tumors, nonclonal abnormalities in one tumor, and only normal karyotypes in five tumors. Clonal abnormalities of chromosome 10 were present in three tumors, two of which had the translocation t(7;10)(q35;q21). Numerical abnormalities of chromosome 17 were detected in two tumors.

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Epithelial‐mesenchymal transitions during cell culture of primary thyroid tumors?

Herrmann

Trevor

1993

Genes Chromosomes & Cancer

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Fibroblast contamination of epithelial tumor cell cultures is of great concern when examining tumor cells in vitro for specific biochemical and cytogenetic changes. The observations of normal karyotypes in thyroid tumor cell cultures have raised the concern of whether residual tissue fibroblasts might obscure the cytogenetic analysis of transformed epithelial cells. We have characterized early passaged thyroid tumor cells to examine the proportions of epithelial and fibroblastic cell types. Cells were analyzed by immunocytology using antibodies recognizing the thyroid prohormone thyroglobulin, epithelial cytokeratins, and vimentin, a mesenchyme marker. Tumors consisted of one follicular adenoma and five papillary carcinomas. When examined by day 15 in culture, all cells contained filaments composed of vimentin, which most likely represents an adaptation to culture conditions. Double immunofluorescence staining for thyroglobulin and cytokeratin revealed the presence of not only epithelial but also spindle-like fibroblastoid cells possessing thyroid epithelial cell markers. The results suggest that in thyroid tumor cultures there is a unique cell type intermediate between epithelial and mesenchyme phenotypes that must be considered when performing cytogenetic analysis.

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Cytogenetics of six follicular thyroid adenomas including a case report of an oxyphil variant with t(8;14)(q13;q24.1)

Cited by 9 publications

References 18 publications

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Cytogenetic studies on 19 papillary thyroid carcinomas

Epithelial‐mesenchymal transitions during cell culture of primary thyroid tumors?

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