Cytogenetics and cell surface marker analysis in chronic myelocytic leukemia. II. Implications for patient management

Fuscaldo, Kathryn E.; Brodsky, Isadore; Crilley, Pamella; Ligler, Frances S.

doi:10.1016/0165-4608(87)90130-0

Cited by 4 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proportion of mixed-lineage blast cells in our series is in keeping with the findings described in previous reports [13,14,16]. This group includes only patients whose transformed blasts have maintained lineage consistency during observation.…”

Section: Discussionsupporting

confidence: 77%

“…The blasts were usually negative for Ia (9 of 11) but positive for CD11, CD13, CD14, and CD33. The contrast between Ia negativity in myeloid transformations and Ia positivity in lymphoid transformations is similar to the observations of Fuscaldo et al [14], and may provide a relatively easy test for distinguishing between lymphoid and non-lymphoid crisis. More importantly, the blast cells of patients who eventually transform to lymphoid blast crisis may show CD10 and Ia positivity months before transformation occurs.…”

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Morphological and Immunological Pattern of Blastic Transformation in Chronic Myeloid Leukemia in Saudi Arabia: Study of 90 Transformations Among 248 Patients

et al. 1991

View full text Add to dashboard Cite

We examined the pattern of blastic transformation in 90 of 248 patients (36%) with chronic myeloid leukemia who were seen at the King Faisal Specialist Hospital and Research Centre between 1975 and1988. The mean and median ages of all patients were 38.2 and 36.0 years, respectively. Four of the 90 transformants (4.4%) presented in blastic transformation, and 86 cases (95.5%) evolved from a well-defined chronic phase. Twenty-nine (32.2%) of the patients underwent lymphoid blastic transformation, while 28 (31.1%) were myeloid, seven (7.8%) were myelomonocytic, four (4.4%) were monocytic or erythroblastic, six (6.7%) were megakaryoblastic, ten (11.1%) were of mixed lineage, and two (2.2%) were unclassifiable. The lymphoid blast cells were uniformly common acute lymphocytic leukemia (i.e., Ia and CD10 positive), whereas the myeloid transformations were predominantly Ia negative. Mixed phenotype blasts were also predominantly Ia positive (i.e., 8 of 10), with varying positivity for CD10 and myeloid/monocytic markers. We conclude that blast crisis in chronic myeloid leukemia occurs in Saudi patients in a pattern similar to that seen in patients elsewhere, and that surface Ia antigen positivity in lymphoblast cells is a reliable marker for differentiating lymphoid from nonlymphoid crisis, in which the Ia antigen is not usually demonstrable.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 64%

Morphological and Immunological Pattern of Blastic Transformation in Chronic Myeloid Leukemia in Saudi Arabia: Study of 90 Transformations Among 248 Patients

et al. 1991

View full text Add to dashboard Cite

show abstract

Malignant Transformation

Kaiser¹

1989

Influence of Tumor Development on the Host

View full text Add to dashboard Cite

T-Cell Blast Crisis in Chronic Myeloid Leukemia

Stewart¹,

Schuh²,

Keating³

1991

Leukemia & Lymphoma

View full text Add to dashboard Cite

Involvement of T cells in chronic myeloid leukemia is a rare event. Twenty-one cases of T-cell lymphoid blast crisis of chronic myeloid leukemia reported in the literature are reviewed, and evidence for T-lineage involvement is evaluated. Patients present with a distinctive clinical phenotype. Most frequently they are young males with extensive extramedullary deposits of blast cells, rapidly progressive lymphadenopathy, organomegaly and pleural involvement. Clonal cytogenetic evolution is common and survival short. The identification of this phenotype may be of clinical and prognostic significance.

show abstract

Cytogenetics and cell surface marker analysis in chronic myelocytic leukemia. II. Implications for patient management

Cited by 4 publications

References 53 publications

Morphological and Immunological Pattern of Blastic Transformation in Chronic Myeloid Leukemia in Saudi Arabia: Study of 90 Transformations Among 248 Patients

Morphological and Immunological Pattern of Blastic Transformation in Chronic Myeloid Leukemia in Saudi Arabia: Study of 90 Transformations Among 248 Patients

Malignant Transformation

T-Cell Blast Crisis in Chronic Myeloid Leukemia

Contact Info

Product

Resources

About