Cytogenetical aspects of miscarriages and reproductive failures at assisted fertilization technologies

Abstract

It is known that chromosomal abnormalities are one of the most important causes of the spontaneous abortions. In this review we have considered the cytogenetical disturbances which can lead to miscarriages and embrio losses at assisted fertilization technologies. We have analyzed the structure of chromosome aberrations in spontaneous abortions and influence of the different types of alterations on the forecasting the future pregnancy outcomes. It has been considered the probability of recurrence of the pregnancy losses in patients-carriers of structural balanced chromosome rearrangements. In vitro fertilization implantation failures like as the miscarriages can depend on presence of chromosome anomalies including the occasions when the parents are the carriers of structural unbalanced rearrangements. So the kariotyping of couples, which require the assisted fertilization technologies, should be the necessary part of preliminary investigation.