Cytogenetic toxicity of<i>Aloe vera</i>(a medicinal plant)

Verma, A. K.; Gupta, Ashok; Kumar, Amod; Khan, Parimal Kumar

doi:10.3109/01480545.2011.567273

Cited by 12 publications

(5 citation statements)

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“…9 A. vera gel has so far been investigated for its cytotoxic and genotoxic effects. 10,11 As was stated by du Plessis and Hamman in 2014, 12 cell viability of A. vera gel on SH-SY5Y cells is affected only at concentrations above 410 mg L −1 . Apart from genotoxicity and cytotoxicity, the antidiabetic 13 , antimicrobial, 6,13,14 and anticancer properties of A. vera extracts have been examined 15 .…”

Section: Introductionmentioning

confidence: 64%

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Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece

et al. 2020

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BACKGROUND: Aloe vera is a popular medicinal plant used widely by the cosmetic, pharmaceutical, and food industries. The A. vera leaf gel, which is used mostly for its positive effects on human health, contains over 75 different bioactive compounds, including aloin. Aloin is a toxic compound, and its content in A. vera leaf gel products depends on the different cultivation conditions and especially on leaf processing. RESULTS: In this study, A. vera leaf gel products, varied in terms of leaf processing, were analyzed using liquid chromatography for their aloin content, their antioxidant activity by 2,2 0-azino-bis(3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS •+) and the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH •) antioxidant activity assays and their toxicity against Aliivibrio fisheri and SH-SY5Y cells. In the samples processed with industrial methods and in those filtered in the lab, the content of aloin was found below the limit (0.1 mg L −1) of the EU legislation however, the unprocessed and unfiltered samples were found to contain more than 10 mg L −1. Antioxidant activity was estimated to vary from 1.64 to 9.21 ∼mol Trolox mL −1 for DPPH • and from 0.73 to 5.14 ∼mol Trolox mL −1 for ABTS •+. Toxicity values on A. fisheri, expressed as the concentration at 50% loss of initial luminescence, ranged from 0.03 to 0.09 mg mL −1. The cytotoxic study indicated that aloin A at low concentrations (1 and 10 ∼g mL −1) protects SH-SY5Y cells from toxicity induced by hydrogen peroxide. CONCLUSIONS: Consequently, the filtration process of A. vera leaf gels, either laboratory or industrial, resulted in aloin A content below the EU legislation detection limits.

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Section: Introductionmentioning

confidence: 64%

“…A. vera gel has so far been investigated for its cytotoxic and genotoxic effects 10,11 . As was stated by du Plessis and Hamman in 2014, 12 cell viability of A. vera gel on SH‐SY5Y cells is affected only at concentrations above 410 mg L −1 .…”

Section: Introductionmentioning

confidence: 89%

Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece

et al. 2020

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“…Devido à ampla utilização popular do gel da A. vera [5,31,32,33,34,35] para o tratamento de lesões de pele, dentre elas, a queimaduras, optou-se por mimetizar a forma como a população faz uso do mesmo, mediante ensaios in vitro, a fim de verificar a atividade antimicrobiana e o potencial citotóxico do gel dessa planta.…”

Section: Resultsunclassified

“…Pela análise morfológica dos eritrócitos expostos a A. vera, também não foi verificado nenhuma alteração quando comparado com o grupo controle. Logo, apesar de nossos dados e da literatura atestarem a segurança de uso, recomenda-se que seu uso seja moderado, e ainda, deve ser levado em consideração o tempo de exposição, pois poucos são os testes de uso crônico desta planta [33,35,48,49].…”

Section: Ensaios De Foe Da Aloe Veraunclassified

Propriedade antimicrobiana e potencial citotóxico in vitro do gel de Aloe vera: uma discussão sobre o uso em queimaduras

et al. 2018

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Estudo experimental que teve por objetivo avaliar a propriedade antimicrobiana e o potencial citotóxico do gel da Aloe vera, a fim de discutir seu uso tópico em queimaduras. Para tanto, foram coletadas na cidade de Palmas-TO folhas da A. vera. O gel obtido após processamento das folhas foi dividido em dois grupos in natura (Amostra A) e liofilizado (Amostra B). A propriedade antimicrobiana foi realizada pelo método de macrodiluição em ágar e microdiluição em caldo para determinação da concentração inibitória mínima (CIM) e da concentração bactericida mínima (CBM), para microrganismos comumente identificados em lesões infectadas de indivíduos queimados. O ensaio de fragilidade osmótica eritrocitária (FOE) foi realizado para avaliação da citotoxicidade. Os resultados sugerem que a Aloe vera possui atividade antimicrobiana de caráter bacteriostática para S. aureus, E. cloacae, A. baumanii, P. aeuruginosa, E. coli e C. albicans, tanto na forma in natura como liofilizada. Quanto à citotoxicidade, não houve taxa de hemólise significativa (p < 0,05), bem como deformidade em membrana celular, que evidenciasse risco tóxico no uso do gel da planta para as concentrações máximas testadas 100% in natura e 20 mg/ml do extrato do gel liofilizado. No que tange ao uso popular no tratamento de queimaduras, as evidências deste estudo corroboram para a segurança do uso tópico. Entretanto, mais estudos de como ocorre a absorção e metabolização devem ser realizados.

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“…However, different genotoxic effects have been observed between distinct preparations from the same plants. For example, the chloroform extract of Aloe vera showed genotoxicity in mitotic index and chromosome aberration tests, but their crude extract and hydroalcoholic extract showed negative results at the same or even higher doses [ 52 , 53 , 54 ]. Therefore, a detailed study is required to evaluate the genotoxicity of noni fruits and seeds under diverse experimental conditions.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity Comparison between Morinda citrifolia Fruit and Seed Substances

Shin

Kim

Park

et al. 2022

Foods

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This study aimed to evaluate the genotoxic potential of the fruit and seed powder, fruit puree, and aqueous extracts of Morinda citrifolia (Rubiaceae, noni). The genotoxic potential of the noni substances was evaluated using in vitro Ames, in vitro chromosomal aberration, and in vivo micronucleus tests. All test procedures were conducted per Organization for Economic Cooperation and Development guidelines, and good laboratory practice. None of the noni fruit test substances showed genotoxic signs up to 5000 and 2000 μg/plate in the Ames and micronucleus tests, respectively. In the chromosomal aberration test, neither the fruit puree nor aqueous extract showed structural and numerical aberrations up to 5000 and 4650 μg/mL, respectively, irrespective of metabolic activation, in both 6 h and 24 h treatment groups. The safe ranges of noni fruit and seed powders were up to 2500 and 2100 μg/mL, respectively, in the 6 h treatment group and up to 1600–4100 and 370–450 μg/mL, respectively, in both 6 h and 24 h treatment groups in the presence of metabolic activation. Noni fruit and seeds were safe in terms of genotoxicity under our experimental conditions. Our data are the first to provide valuable genotoxic information on Morinda citrifolia.

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Cytogenetic toxicity ofAloe vera(a medicinal plant)

Cited by 12 publications

References 30 publications

Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece

Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece

Propriedade antimicrobiana e potencial citotóxico in vitro do gel de Aloe vera: uma discussão sobre o uso em queimaduras

Genotoxicity Comparison between Morinda citrifolia Fruit and Seed Substances

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