Cytogenetic study on individuals occupationally exposed to DDT

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

“…Em trabalhadores rurais e da indústria de pesticidas, observou-se uma forte associação entre alterações cromossômicas e a exposição a produtos comercialmente conhecidos como Ziram, Zineb, Thiram, Triclorfom, Fosmet, Dazinon e Primicarb (Pàldy et al, 1987). Em relação ao efeito clastogênico, enquanto que o DDT demonstrou relação positiva na indução de quebras cromossômicas (Rabello et al, 1975), nenhum aumento apreciável foi observado em trabalhadores expostos ao Lidane (Kiràly et al, 1979). Resultados negativos na análise cromossômica também foram relatados em relação a Clorinol e Buvinol (Czeizel et al, 1976) e ainda, ao Dicloropropano (Kapp et al, 1979).…”

Frequency of sister chromatid exchange and hematological effects in pesticide-exposed greenhouse sprayers

“…Observations of cytotoxic effects from single pesticides or mixtures of pesticides are mainly derived from a variety of shortterm test studies or case reports (1)(2)(3)(4)(5). In previous epidemiologic investigations significant increases in chromosome damage have been observed in cultured lymphocytes from pesticide-exposed workers (6)(7)(8)(9)(10). Other studies have failed to detect cytogenetic damage (11)(12)(13)(14).…”

Presence of Dichlorodiphenyltrichloroethane (DDT) in Croatia and Evaluation of Its Genotoxicity

“…In vitro, certain DDT concentrations have the effects on human leukocyte functions (Lee et al, 1979), are causing chromosomal aberrations (Lessa et al, 1976), DNA strand breaks , and apoptosis induction which is preceded by an increase in the levels of reactive oxygen species (Pérez-Maldonado et al, 2004, 2005. In vivo, DDT is able to induce chromatid lesions (Rabello et al, 1975), increase in chromosomal aberrations and sister chromatid exchanges (Rupa et al, 1989(Rupa et al, , 1991, DNA strand breaks Pérez-Maldonado et al, 2006), apoptosis (Pérez-Maldonado et al, 2004) as well as cell cycle delay and decrease in mitotic index (Rupa et al, 1991). Before 1973 when it was banned, DDT entered the air, water and soil during its production and use as an insecticide.…”