Cytogenetic Study of the Offspring of Atom Bomb Survivors

Cytogenetic "rogue" cells: what is their frequency, origin, and evolutionary significance?

“…The proximally exposed survivors received from 1 rem (1 rem = 0.01 S-v) of radiation up to the maximum consistent with survival; the distally exposed parents received essentially no radiation at the time of the bombing. These children were being studied in a search for evidence of transmitted chromosomal damage (8,9); the findings to be described here are an incidental observation that, as we will show, is unrelated to the radiation history of the parents.…”

Delayed Radiation Effects in Atomic-Bomb Survivors

“…Finding these abnormalities even among persons exposed during the first trimester in uteco indicates that radiation can induce long-persisting changes in the lymphocyte precursors. In contrast to the cytogenetic defects observed following intrauterine (postconception) exposure, no such defects were found following preconception irradiation (exposure of either parent before conception of the child) (8).…”

Long-term Radiation-Related Health Effects in a Unique Human Population: Lessons Learned from the Atomic Bomb Survivors of Hiroshima and Nagasaki

“…The frequency of F 1 individuals with cytogenetic numerical or structural abnormalities based on Giemsa-staining methods was 0.5% to 0.6% in both children from exposed parent(s) (8322) and children from unexposed parents (7976) 72. De novo cytogenetic structural rearrangements were seen in 0.02% of children (with both parents unaffected) with no indication of a parental radiation exposure effect.…”