Cytogenetic study of patients with carcinoma of the colon and rectum: Particular C-band variants as possible markers for cancer proneness

Variations in centromeric heterochromatin among patients with pre‐malignant and malignant oral diseases

“…It was noteworthy that 16 was not involved in variations of either size or localization. These findings compare well with many other reports expressing increased frequency of inversions in either chromosome 1 or 9 or both (Petkovic, 1983;Shabtai and Halbrecht, 1979;Shabtai et al, 1985). Taking into consideration both the qualitative and quantitative approaches, the presence of both these events in same individual was more prevalent among the patients.…”

“…Although most studies support the association of C-band heteromorphism with the occurrence of cancer (Shabtai and Halbrecht, 1979;Berger et al, 1979Berger et al, , 1985Petkovic, 1983;Labal de Vinuesa et al, 1988;Adhvaryu et a[., 1987;Sampaio et al, 1989), a few have reported the contrary (Aguilar et al, 1981;Kivi andMikelsaar, 1980, 1987;Berger et al, 1983). Differences in C-band patterns have been observed in various ethnic groups (Lubs et al, 1977) and it has been suggested that different factors may affect predisposition to cancer in different populations (Shabtai et al, 1985).…”

Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia

“…However, the results are contradictory; some authors found an increased incidence of inv (9) in malignant diseases [36,38,[40][41][42], while others did not [30,31,33,34,37,39,43]. The pathogenesis of this case remains unclear, especially whether inv(9) has contributed to the development of CLL or the secondary HD.…”

“…Cytogenetic analysis in CLL patients with spontaneous remission has been performed in four cases only; all of them showed a normal karyotype [15,21]. Variability of the human chromosome constitutive heterochromatin areas, so called C-band variants, on chromosome 1, 9, and 16 is frequently observed, including abnormality of size, size heteromorphism, and (pericentric) inversions [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Familial occurrence of cancer and heteromorphism of the heterochromatic segment of chromosome 1

“…It has been suggested that individuals displaying increased quantities of constitutive heterochromatin or considerable heteromorphism of the C-bands of chromosome 1 may be more prone to chromosomal instability in somatic cells, perhaps due to increased rates of chromosome breakage and/or of somatic crossing over, thus facilitating genetic changes during neoplastic transformation 198.5). Several workers have found positive correlations between heteromorphism of constitutive heterochromatin in chromosome 1 and the development of various kinds of neoplasia, such as ovarian cancer (ATKIN and PICKTHALL 1977), carcinoma and dysplasia of the uterine cervix (HENEEN et al 1980;GHOSH et al 1986), breast cancer (BERGER et al 1985), malignancies of the head and neck (PET- KOVIC 1983), various solid tumors (SUCIU 1986), carcinoma of the colon and rectum (SHABTAI et al 1985), bladder carcinoma (ATKIN and BAKER 1977), chronic myeloid leukemia (BERGER et al 1979;SHABTAI and HALBRECHT 1979;RAJASEKARIAH and GARSON 1981;ADHVARYU et al 1987), acute leukemia and preleukemia (SHABTAI and HALBRECHT 1979;VINUESA et al 1984, 198.5), and multiple (reviewed by BRITO-BABAPULLE 1981, myeloma (RANNI et al 1987). In contrast, some workers could not find any correlation between Cband heteromorphism in chromosome 1 and cancer susceptibility in their studies of ovarian and breast carcinomas (KIVI andMIKELSAAR 1980, 1987), testicular tumors (ROBSON et al 1981), soft tissue sarcomas (BERGER et al 1983), tumors of the nervous system (REY et al 198.5, 1987), adenomatosis of the colon and rectum (HEIM et al 198S), and acute nonlymphocytic leukemias (CONIAT et al 1982).…”