Abstract:Background: Down syndrome (DS) is the most common type of chromosomal trisomy found in new-born. It's associated with mental retardation and characteristic facial features. A clinical diagnosis of Down syndrome may be unconfirmed in one third of cases.Objective: This study was conducted to confirm the clinical diagnosis of suspected cases with Down syndrome by a cytogenetic analysis and to evaluate several risk factors associated with trisomy 21 in a group of patients from West region of Algeria, Tlemcen.
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