Cytogenetic studies on women using oral contraceptives and their progeny

McQuarrie, Howard G.; Scott, Charles D.; Ellsworth, Homer S.; Harris, J. W.; Stone, Rodney A.

doi:10.1016/0002-9378(70)90249-8

Cited by 45 publications

(7 citation statements)

References 4 publications

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“…During this period, the change in the total number of FS seems to be similar to the change in serum progesterone concentration, but not estradiol. Increased chromosomal breaks have been reported in women taking hormonal oral contraceptives and in pregnant women (McQuarrie et al 1970;Littlefield et al 1975;Pinto 1986). These studies indicate that estrogen and progesterone, especially progesterone, influence the frequencies of chromosomal breaks.…”

Section: Discussionmentioning

confidence: 99%

“…The numbers of chromosomal gaps and breaks and sister chromatid exchanges (SCE) are known to increase in pregnant women and in women taking oral hormonal contraceptives (McQuarrie et al 1970;Littlefield et al 1975;Pinto 1986;Sharma and Das 1986). The numbers of chromosome aberrations and SCE increase during the follicular phase compared with that of the luteal phase of the menstrual cycle (D'Souza et al 1988).…”

Section: Introductionmentioning

confidence: 99%

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Changes of common fragile sites on chromosomes according to the menstrual cycle

Furuya

Hagiwara²,

Ochi³

et al. 1991

Hum Genet

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The frequencies of chromosomal breaks and sister chromatid exchanges (SCE) are influenced by pregnancy, oral hormonal contraceptives and the menstrual cycle. The changes in the number and sites of spontaneous and aphidicolin-induced breaks on chromosomes from peripheral blood lymphocytes during the menstrual cycle were examined in 8 healthy women. Menstrual cycle was determined by menstruation and the quantity of serum estrogen, progesterone and luteinizing hormone. The number of spontaneous breaks at the follicular phase, the interval phase (which includes ovulation) and the luteal phase were 3.1 +/- 1.1, 2.7 +/- 2.3 and 3.9 +/- 2.6 per 100 mitoses, respectively. The frequencies of aphidicolin-induced breaks in the same phases were 95.8 +/- 23.3, 90.6 +/- 14.3 and 122.7 +/- 20.1 per 100 mitoses, respectively. The higher frequency at the luteal phase was statistically significant compared with the other phases. In the luteal phase, bands 2q32, 3q27, 6q26 and 16q23 had higher frequencies of breaks (P less than 0.05); however, breaks at band 9q32 decreased significantly. SCE showed considerable variation, but with no statistical significance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes of common fragile sites on chromosomes according to the menstrual cycle

Furuya

Hagiwara²,

Ochi³

et al. 1991

Hum Genet

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“…The numbers of chromosomal breaks and sister chromatid exchanges are elevated in women who are pregnant or taking oral contraceptives [114–117]. Furthermore, women currently taking oral contraceptives have an increased incidence of thyroid cancer, including a stronger association with PTC than other subtypes [118].…”

Section: 5 Ptc In Womenmentioning

confidence: 99%

The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma

Dillon

Lehman

Wang

2012

Journal of Thyroid Research

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The incidence of thyroid cancer is increasing, especially papillary thyroid carcinoma (PTC), making it currently the fastest-growing cancer among women. Reasons for this increase remain unclear, but several risk factors including radiation exposure and improved detection techniques have been suggested. Recently, the induction of chromosomal fragile site breakage was found to result in the formation of RET/PTC1 rearrangements, a common cause of PTC. Chromosomal fragile sites are regions of the genome with a high susceptibility to forming DNA breaks and are often associated with cancer. Exposure to a variety of external agents can induce fragile site breakage, which may account for some of the observed increase in PTC. This paper discusses the role of fragile site breakage in PTC development, external fragile site-inducing agents that may be potential risk factors for PTC, and how these factors are especially targeting women.

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“…McQuarri et al [23], Littlefield et al [24], Bynum et al [25], and Hill and Wolff [26] reported an increased number of chromosomal breaks and rearrangements in lymphocytes of women using OCs. Murthy and Prema [27,28], observed a significantly increased frequency of sister chromatid exchanges in OC users.…”

Section: Introductionmentioning

confidence: 99%