Abstract:Pepon and prostoplex, new drugs containing natural substances, are used in the treatment of prostatic disorders. The cytogenetic effects of these drugs were tested in mice's bone marrow and spermatocytes cells at two doses comparable to propose human therapeutic and double therapeutic doses. The results revealed that the total numbers of structural chromosomal aberrations in mice's bone marrow, with or without gap, were significantly increased at pϽ0.01 for pepon and at pϽ0.05 for prostoplex at therapeutic dos… Show more
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