Cytogenetic Studies and Their Clinical Correlates in Adults with Acute Leukemia

Cytogenetic Studies in Acute Leukaemias. Prognostic Implications of Chromosome Imbalances

“…While Sakurai and Sandberg [15] and G olomb et al [7] have found worse prognosis in subjects with ab normal karyotypes than in those with normal ones, F ord et al [6], H art et al [10] and Fitzgerald et al [5] have denied the possibility to correlate the prognosis with the cytogenetic findings. Our data indicate a median survival of 55 days in the 16 ANLL patients with abnormal karyotypes and of 210 days in the 14 ANLL patients with normal karyo types.…”

DNA Content Analysis by Flow Cytometry and Cytogenetic Analysis in Mycosis Fungoides and Sézary Syndrome

“…14 patients were sttudied while in remission; aneuploidy was present in four patients (29%) ( Table II). Previous studies had been performed in 13 of these patients; 6 initially aneuploid (wide GC peak) became normal; 3 remained normal; 4 peaks in 10 and an increased CV ratio in 12. Chromosome analysis revealed numerical abnormalities consistent with the DI of the discrete peak in each of these 10 samples (Table IV).…”

“…In some leukemias there is evidence that cytogenetic analysis provides prognostic information. In these instances, cytogenetic changes are associated with a transformation in the cliniical course to a more aggressive n-ature with a poor prognosis (2)(3)(4)(5)(6). Cytogenietic analysis is, however, limited by requirements for live sinigle cells with a relatively high proliferative rate; few cells are analyzed.…”

“…In these patients, aneuploidy was fre(uently detected in bloo1( and lymph node specimiiens scored as negative by cytology anid histology, suggestinig that unsuspected extracutanieous dissemination is presenit in many patienits at the time of' diagnosis. Direct (1)(2)(3)(4)(5). In some leukemias there is evidence that cytogenetic analysis provides prognostic information.…”

“…Cutaneous T-cell lymphomas, including mycosis fungoides and the S6zary syndrome, are malignant disorders of thymus-derived lymphocytes (T cells) (18)(19)(20) 11 at diagnosis and remission, 4 at diagnosis and relapse, 2 at diagnosis, remission, and relapse, 1 only in remission, and 7 only in relapse. Six of the eight patients studied only in remission or relapse had previously received systemic chemotherapy and one had previously received whole body electron beam irradiation.…”