Cytogenetic Profile of Childhood Acute Lymphoblastic Leukemia in Oman

Udayakumar, Achandira M.; Bashir, Wafa; Pathare, Anil; Wali, Yasser; Zacharia, Mathew; Khan, Ayesha; H, Soliman; Al-Lamki, Zakia; Raeburn, J. A.

doi:10.1016/j.arcmed.2006.10.006

Cited by 11 publications

(9 citation statements)

References 45 publications

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“…This was similar to that reported by Secker-Walker et al [16] and by Udayakmar et al [10] but lower to that reported by Williams et al [17] and Jarosova et al [18] who detected abnormal karyotypes in more than 90% of cases.…”

Section: Discussionsupporting

confidence: 91%

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Gmidène¹,

Sennana²,

Elghezal³

et al. 2008

Hematological Oncology

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Genetic changes associated with Acute Lymphoblastic Leukaemia (ALL) provide diagnostic and prognostic information with a direct impact on patient management. We report the cytogenetic analysis of 298 Tunisian patients with ALL, including 183 children and 115 adults. Chromosome abnormalities have been detected in 68.2% of our patients associating clonal numerical and/or structural rearrangements. Some chromosomal abnormalities especially hyperdiploidy, 19p13 abnormalities, 8q24 translocations, 12p, 6q deletions and TCR rearrangements occur at a lower incidence compared to that reported in other populations. ALL cases (5.7%) had miscellaneous clonal abnormalities. We also found in our Tunisian series a higher incidence for T-lineage ALL more than usually described. Among structural chromosomal abnormalities, t(9;22)(q34;q11) resulting in the BCR/ABL fusion and the t(12;21)(p13;q22) resulting in the TEL/AML1 fusion were studied by FISH providing additional diagnostic and prognostic information. We conclude that although the incidence of our cytogenetic results are slightly different, their clinical significance is similar to that described in the literature.

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Section: Discussionsupporting

confidence: 91%

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Gmidène¹,

Sennana²,

Elghezal³

et al. 2008

Hematological Oncology

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“…TEL-AML1 is related with good prognosis and commonly found in ALL children aged between one to nine years. 17,18 This study found that ALL incidence in male were almost two times higher than female (64% vs 36%), similar with many previous studies in Myanmar, 17 Oman, 16 Argentina, 13 and Pakistan. 18 Pallor, fever, bone pain, bleeding, lymphadenopathy, hepatomegaly, and splenomegaly as main clinical symptoms in ALL were more prominent in poor responders.…”

Section: Discussionsupporting

confidence: 82%

“…15 The age distribution was similar with previous study in Oman that found 13% childhood ALL patient were aged <1 year, 77% were aged between one to 10 years, and 11% were aged >10 years. 16 In this study, 81% of patient aged one to <10 years old had good response, while 75% of patient <1 year old and 78% patient aged ≥10 years old had poor response. Age is known as an important prognostic factor, with many studies showing that patient aged <1 and >9 years old had poor prognosis.…”

Section: Discussionmentioning

confidence: 49%

Steroid response as prognostic factor and its correlation with molecular assessment of childhood acute lymphoblastic leukemia

et al. 2015

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ABSTRAK ABSTRACTBackground: Survival rate of children with acute lymphoblastic leukemia (ALL) in Indonesia remains low. Risk stratification accuracy is important to improve survival. In developed countries, risk stratification is determined based on gene fusion that is known related to steroid resistency. Steroid response at day-8 correlates with prognosis. The assessment can be applied in centers that cannot perform molecular assessment. This study aims to evaluate whether steroid response correlated to molecular assessment.

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“…Thus, we suggest that in our case, with an early pro-T phenotype and the expression of CD34, the TCR γ has quite likely not yet been rearranged. The detected mutation of the NRAS gene and monosomy 18 only in the pro-T LBL component are in line with the well-known RAS gene family mutations in early T-cell-derived ALL [27] and with the reported cytogenetic anomalies in ALL [28]. Since the NRAS gene was not mutated in the IDCT, the G13D mutation might have represented a secondary genetic event in the pro-T LBL component, which corresponds with the putative role of RAS family member mutations as progression and not driver mutations [29].…”

Section: Discussionsupporting

confidence: 76%

Unique Composite Hematolymphoid Tumor Consisting of a Pro-T Lymphoblastic Lymphoma and an Indeterminate Dendritic Cell Tumor: Evidence for Divergent Common Progenitor Cell Differentiation

et al. 2014

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Until recently, hematopoietic neoplasms were considered monoclonal proliferations belonging to one cell lineage. In the last years, evidence for transdifferentiation from one cell lineage to another or divergent common progenitor cell differentiation has accumulated, mainly based on composite hematolymphoid tumors, sharing common genetic abnormalities. We report the case of a 59-year-old woman with a composite pro-T lymphoblastic lymphoma (LBL) and indeterminate dendritic cell tumor infiltrating the lymph nodes, bone marrow and stomach. Genetic analyses revealed that both cell populations bore +21, while a G13D mutation of the NRAS gene and monosomy 18 were detected only in the pro-T LBL. The synchronous appearance of two distinct uncommon hematolymphoid tumors in the same patient, recurrent at three different anatomic locations, with an identifiable common genetic denominator, namely +21, but also with unique genetic anomalies in the pro-T LBL raises the hypothesis of a divergent common progenitor cell differentiation.

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Cytogenetic Profile of Childhood Acute Lymphoblastic Leukemia in Oman

Cited by 11 publications

References 45 publications

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Steroid response as prognostic factor and its correlation with molecular assessment of childhood acute lymphoblastic leukemia

Unique Composite Hematolymphoid Tumor Consisting of a Pro-T Lymphoblastic Lymphoma and an Indeterminate Dendritic Cell Tumor: Evidence for Divergent Common Progenitor Cell Differentiation

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