Cytogenetic findings in phyllodes tumor and fibroadenomas of the breast

Barbosa, Miriam L.; Ribeiro, Enilze M.S.F.; Silva, Guaracira F.; Maciel, Marcos Euzébio; Lima, Rubens Silveira de; Cavalli, Luciane R.; Cavalli, Iglenir João

doi:10.1016/j.cancergencyto.2004.02.005

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…36 Cytogenetically, phyllodes tumour shows karyotype abnormalities, mostly chromosome gains. 74 As such changes and the implications of their role in histogenesis become more clearly understood, they may in future be useful both for diagnosis of difficult cases and for tumour grading.…”

Section: Role Of Markers Of Cell Proliferationmentioning

confidence: 99%

Optimising preoperative diagnosis in phyllodes tumour of the breast

Jacklin

Ridgway²,

Ziprin³

et al. 2006

J Clin Pathol

131

126

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The role of the pathologist in the preoperative diagnosis of phyllodes tumours of the breast is critical to appropriate surgical planning. However, reliable differentiation of phyllodes tumour from cellular fibroadenoma remains difficult. Preoperative diagnostic accuracy allows correct surgical treatment, avoiding the pitfalls of reoperation because of inadequate excision, or surgical overtreatment. Specific clinical indices may arouse diagnostic suspicion but are unreliable for confirmation, as with current imaging modes. Fine needle aspiration cytology has a high false negative rate. Few studies have evaluated the role of core needle biopsy, but it may prove a useful adjunct. Both diagnostic and prognostic information may in future be gained from application of immunohistochemical and other techniques assessing the expression of proliferative markers including p53, Ki-67, and others.

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Section: Role Of Markers Of Cell Proliferationmentioning

confidence: 99%

Optimising preoperative diagnosis in phyllodes tumour of the breast

Jacklin

Ridgway²,

Ziprin³

et al. 2006

J Clin Pathol

131

126

View full text Add to dashboard Cite

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“…Numerical chromosome aberrations involving chromosome 21 are rarely described in the literature [21]. Chromosome 21 loss has already been reported in benign breast tumours, such as epithelial hyperplasia and phyllodes tumours [3,22]. However, chromosome 21 monosomy is not frequently found in breast cancer [21].…”

Section: Discussionmentioning

confidence: 99%

“…Data from the literature show that clonal alterations involve chromosomes 1, 4, 6, 12, 17 and 20 in structural rearrangements, and chromosomes 5,8,11,12,16,17,18,19,20 and 21 in aneuploidies [3,4,7,8]. Most FAs do not exhibit any detectable cytogenetic abnormalities [4].…”

Section: Introductionmentioning

confidence: 95%

“…Women can present with this lesion at any age, but it is more commonly diagnosed in young women aged around 20-36 years [2][3][4], in which breast cancer is not common. This can explain why FAs are not directly related with breast cancer [5].…”

Section: Introductionmentioning

confidence: 98%

“…FAs present as mobile and well outlined nodules, generally <4 cm in diameter. The stromal component of FAs can progress toward phyllodes tumours, which have malignisation potential [3,4]. Malignant transformations of epithelial components have been reported in 0.02%-0.3% of cases, usually originating in lobular carcinoma in situ [1,3,5,6].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of chromosome 21 aneuploidies in breast fibroadenomas by fluorescence in situ hybridisation

et al. 2006

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Fibroadenoma (FA) is a benign breast tumour that occurs in about 25% of women. Cytogenetic studies suggest that numerical chromosomal aberrations may contribute to tumorigenesis, but chromosomal instability is still poorly characterised in breast cancer. The aim of this study was to investigate numerical alterations of chromosome 21 in 15 breast FAs. All samples were analysed by classical cytogenetics and by fluorescence in situ hybridisation (FISH) for chromosome 21 DNA sequences. Classical cytogenetics analysis showed that all cells were diploidies with modal number varying between 43 and 47 chromosomes, and clonal chromosome alterations in 46.7% of tumours. Clonal numerical alterations involved, preferentially, chromosomes 8, 10, 12, 16 and 21. FISH analysis showed a statistically significant difference for chromosome 21 monosomy between seven samples and control group. This monosomy varied from 24.5% to 43.5% of analysed cells. The presence of chromosomal alterations in FAs may be a consequence of the proliferation process and is probably not related to the aetiology of this type of lesion. The study of benign proliferations and comparison with chromosome alterations in their malignant counterparts should result in an understanding of the genes acting in cell proliferation alone and those that cause these cells to both undergo malignant transformation and become invasive.

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