Cytogenetic Findings in Erythroleukemia

Heath, Clark W.; Bennett, John M.; Whang‐Peng, Jacqueline; Berry, Elizabeth W.; Wiernick, Peter H.

doi:10.1182/blood.v33.3.453.453

Cited by 50 publications

(3 citation statements)

References 12 publications

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“…Six of these patients, including the one with leukaemia, were considered to have cell populations in the bone marrow with different structural aberrations involving one chromosome in the F group. Four out of six cases studied by Heath et al (1969) had chromosome abnormalities in the bone marrow. Different hypodiploid cell lines were found in two patients and a high frequency of polyploid cells in a third.…”

Section: Table VI Percentage Of Cells With Different Chromosome Constmentioning

confidence: 96%

An Extra C Chromosome and Various Metabolic Abnormalities in the Bone Marrow from a Patient with Refractory Sideroblastic Anaemia

Hellström

Hagenfeldt

Larsson

et al. 1971

Scandinavian Journal of Haematology

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A clinical, cytological and biological study of a 57‐year‐old man with a sideroblastic anaemia is presented. A large population of cells with 47 chromosomes and an extra C chromosome was found in the bone marrow cells but not in skin cells or lymphocytes. The concentration of uracil nucleotides in the bone marrow of the patient was increased. When incubated with 3H‐thymidine the erythroblasts of the patient's marrow showed a low labelling index, A considerable number of early erythroblasts not incorporating thymidine had an intermediate DNA content indicating an arrest in DNA synthesis. A normal labelling index was recorded for the myelopoietic cells.

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Section: Table VI Percentage Of Cells With Different Chromosome Constmentioning

confidence: 96%

An Extra C Chromosome and Various Metabolic Abnormalities in the Bone Marrow from a Patient with Refractory Sideroblastic Anaemia

Hellström

Hagenfeldt

Larsson

et al. 1971

Scandinavian Journal of Haematology

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“…Thus, Kowley31 reported two female patients with Fic. 10. Partial Q-banding karyotype of a cell from case J B showing the possible direction of karyotypic-evolution in four different clones.…”

Section: Msmentioning

confidence: 99%

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Oshimura

Hayata

Kakati

et al. 1976

Cancer

115

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Chromosomes were studied in the bone marrow and/or blood cells from 38 patients with acute myeloblastic leukemia (AML). The initial analysis with conventional Giemsa staining revealed that 16 of the 38 patients with AML studied had chromosomal abnormalities. The cells of these 38 patients (16 with abnormal karyotypes and 22 with normal karyotypes) were re-examined with Q- and G-banding techniques. Twenty-two patients with conventionally stained normal karyotypes did not show any abnormalities, even with banding techniques. Three cases had a common translocation between the long arm of No. 8 and No. 21, i.e., [t(8;21)(q22;q22)], the so-called prototypic karyotype. Two cases had a 45, XX,-21 karyotype; and three cases had trisomy of the long arm of chromosome No. 1. The banding patterns revealed that in two of the three latter cases, the presence of the trisomy of the long arm of No. 1 apparently occurred late in the disease. Therefore, it is possible that the trisomy of the long arm of No. 1 might bear a relationship to selective growth advantage of the leukemic cells in some cases with AML. The presence of extra No. 8 and No. 9 chromosomes and deletion of the long arm of No. 7, frequently reported in several leukemic disorders, were also found in the present cases, but with other chromosomal abnormalities. Chromosomes No. 6,No. 15,No. 19,No. 20, and X were not involved in any structural and/or numerical changes. The present data suggest that some chromosomal changes are nonrandom in AML and that further chromosomal studies may lead to a division of AML patients into subgroups on the basis of their karyotypes.

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“…At the time, it was unclear whether Di Guglielmo syndrome should include the pure erythroblastic manifestations of disease (5). Subsequent cytogenetic characterization studies in erythroleukemia revealed various complex cytogenetic abnormalities akin to those observed in acute myeloid leukemias (AML) (6, 7). Erythroleukemia (EL) was ultimately removed from the rubric of chronic MPDs as it was increasingly recognized as a forerunner of an acute leukemic process (8, 9).…”

Section: Introduction and Historical Perspectivementioning

confidence: 99%

Erythroleukemia-historical perspectives and recent advances in diagnosis and management

et al. 2018

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Acute erythroleukemia is a rare form of acute myeloid leukemia recognized by its distinct phenotypic attribute of erythroblastic proliferation. After a century of its descriptive history, many diagnostic, prognostic, and therapeutic implications relating to this unique leukemia subset remain uncertain. The rarity of the disease and the simultaneous involvement of its associated myeloid compartment have complicated in vitro studies of human erythroleukemia cell lines. Although murine and cell line erythroleukemia models have provided valuable insights into pathophysiology, translation of these concepts into treatment are not forthcoming. Integration of knowledge gained through a careful study of these models with more recent data emerging from molecular characterization will help elucidate key mechanistic pathways and provide a much needed framework that accounts for erythroid lineage-specific attributes. In this article, we discuss the evolving diagnostic concept of erythroleukemia, translational aspects of its pathophysiology, and promising therapeutic targets through an appraisal of the current literature.

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Cytogenetic Findings in Erythroleukemia

Cited by 50 publications

References 12 publications

An Extra C Chromosome and Various Metabolic Abnormalities in the Bone Marrow from a Patient with Refractory Sideroblastic Anaemia

An Extra C Chromosome and Various Metabolic Abnormalities in the Bone Marrow from a Patient with Refractory Sideroblastic Anaemia

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Erythroleukemia-historical perspectives and recent advances in diagnosis and management

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