Cytogenetic findings in a supratentorial ependymoma

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

“…Gonosomal loss has been described previously among CNS tumors, including ependymomas (Bown et al, 1988;Dal Cin et al, 1988;Stratton et al, 1989;James et al, 1990;Thiel et al, 1992;Rogatto et al, 1993;Wernicke et al, 1995), glial tumors of all histologic grades (Rey et al, 1987a(Rey et al, , 1987bJenkins et al, 1989;Lindströ m et al, 1991;Thiel et al, 1992;Mohapatra et al, 1995;Schö ck et al, 1996;Bigner et al, 1997), meningiomas (Zankl et al, 1975), and medulloblastomas (Reardon et al, 1997), as well as many non-CNS tumors (Mitelman, 1994). Given the propensity for sex chromosome loss during aging (Pierre et al, 1971) and in nontumorigenic tissues including the CNS (Heim et al, 1989), the biologic significance of X chromosome loss among these glial-derived tumors is unclear and warrants further investigation.…”

Ependymomas in Two Sisters and a Maternal Male Cousin with Mosaicism with Monosomy 22 in Tumour

“…Few cytogenetic banded analyses on ependymomas have been performed [25][26][27]. There have been previous reports o f normal diploid cell lines, polyploidy, translo cations, trisomies (often multiple) and a nonrandom in volvement of chromosomes 7, X, Y, and 22, with no definite predom inant abnormality.…”

Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas

“…Chromosome 11 was abnormal in 5 ependymomas in our 2 series. Including a previously published case (Dal Cin and Sandberg, 1988), 3 ependymomas have been observed to have cytogenetic alterations of llq13 and 3 have been found to have genetic alterations of llp. James et al (1990) reported LOH studies on 4 ependymomas.…”