Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine

Mpountoukas, Panagiotis; Pantazaki, Αnastasia A.; Kostareli, Efterpi; Christodoulou, Pantelitsa; Kareli, Dimitra; Poliliou, Stamatia; Mourelatos, Costas; Lambropoulou, Vasso; Lialiaris, Theodoros

doi:10.1016/j.fct.2010.07.030

Cited by 274 publications

(149 citation statements)

References 75 publications

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“…If we define the healthfulness of food by its nutritional quality and lack of pesticide residues (Smith-Spangler et al 2012), there is strong support from the literature based on the possible negative effects of non-organic food on humans due to pesticide residues (Hauser et al 2015;Blair et al 2015), GMOs (Vendomois et al 2010), antibiotic-resistant bacteria (WHO 2011SmithSpangler et al 2012), veterinary drug residues (FAO 2011a, b) and food additives such as colorants (Mpountoukas et al 2010). Food safety is among the important reasons to buy organic food (Hemmerling et al 2015).…”

Section: Product Quality and Human Healthmentioning

confidence: 99%

Organic Agriculture 3.0 is innovation with research

Rahmann¹,

Ardakani

Bàrberi

et al. 2016

Org. Agr.

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Section: Product Quality and Human Healthmentioning

confidence: 99%

Organic Agriculture 3.0 is innovation with research

Rahmann¹,

Ardakani

Bàrberi

et al. 2016

Org. Agr.

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“…Among the flavorings, some of them inhibit microbial proliferation, we can cite potassium benzoate, sodium benzoate and potassium nitrate. They are clastogenic, mutagenic and cytotoxic compounds on normal peripheral human blood cells (Brasil 1999, Mpountoukas et al 2010, Zequin et al 2011. Moreover, boric acid, citric acid, potassium citrate and sodium citrate are cytotoxic on meristematic cells of A. cepa (Brasil 1999, Türkoğlu 2007.…”

Section: Resultsmentioning

confidence: 99%

Are salty liquid food flavorings in vitro antitumor substances?

Carvalho

Moura

Rodrigues

et al. 2016

An. Acad. Bras. Ciênc.

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The objective of this study was to evaluate the antiproliferative, cytotoxic and genotoxic potential of salty liquid synthetic flavorings of Butter, Cheddar Cheese and Onion. The antiproliferative potential (2.9-1500 µg/mL) was assessed by MTT assay after 72h using the human tumor lines SF-295 (glioblastoma), OVCAR-8 (ovarian), HCT-116 (colon) and HL-60 (promyelocytic leukemia) and primary cultures of murine Sarcoma 180 (S180) and peripheral blood mononuclear cells (PBMC). Allium cepa bulbs were exposed to growing respective doses (1 mL and 2 mL). Only Butter and Cheddar flavorings revealed cytotoxic activity on cancer cells, with IC 50 values ranging from 125.4 µg/mL (Cheddar -HCT-116) to 402.6 µg/mL (Butter -OVCAR-8). Butter flavoring was the most cytotoxic on PBMC (136.3 µg/mL) and increased cell division rate in relation to the mitotic index but did not cause cellular aberrations. Onion and Cheddar flavorings reduced the mitotic index after 24h and 48h exposure, but only Onion flavoring resulted in cellular aberrations and mitotic spindle abnormalities, such as anaphase and telophase bridges, micronucleated cells, conchicine-metaphases and amplifications. So, Butter, Onion and/or Cheddar flavorings caused significant changes in the division of meristematic cells of A. cepa and presented cytotoxic action even on decontrolled proliferating human tumor cells.

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“…Entretanto, a ingestão dessas substâncias tem sido associada a efeitos nocivos como: hiperatividade, citoxicidade, genotoxicidade e ansiedade. [41][42][43] Esse cenário tem impulsionado o mercado consumidor a escolher produtos à base de corantes naturais, posto que apesar de mais caros, são mais seguros e, muitas vezes, apresentam propriedades funcionais, 4 a exemplo das betalaínas, antocianinas e carotenoides que podem atuar na proteção do DNA e como agentes hipoglicêmicos e antioxidantes, 44,45 respectivamente.…”

Section: Indústria De Alimentosunclassified

Carotenoids: Properties, Applications and Market

Mesquita¹,

Teixeira²,

Sérvulo³

2017

Rev. Virtual Quim.

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Abstract:The increase of natural products demand has motivated the replacement of artificial colorants for natural ones, because, according to some researches, the consumption of artificial pigments can cause health damage. Carotenoids are natural lipophilic pigments, which can present the colors yellow, orange or red. They are widely distributed in nature in algae, plants, crustaceans, fishes, birds and microorganisms. These colorants can be applied in several kinds of industries, not only with the purpose of coloring, but also to enrich foods and even as food supplement components, animal feed, pharmaceuticals and cosmetics. In face of the carotenoid demand, it is estimated that the world market will move substantial amounts of money in the coming years. Considering this fact, in the Brazilian scenario, there can be an increase in imports, while the exports may remain as the last six years, with small changes, since in Brazil there are no investments on technology development for carotenoid production.Keywords: Natural colorants; carotenoids; carotenoids properties; carotenoids applications; carotenoids market. ResumoA crescente busca por produtos naturais tem motivado a substituição de corantes artificiais por naturais, pois segundo alguns estudos, o consumo de corantes artificiais pode causar danos à saúde. Os carotenoides são corantes naturais, lipofílicos, com coloração amarela, laranja ou vermelha e se encontram amplamente distribuídos na natureza em algas, plantas, crustáceos, peixes, aves e microorganismos. Esses pigmentos podem ser aplicados em diversas indústrias, não somente com a finalidade de colorir, como também para enriquecer alimentos e até mesmo compor suplementos alimentares, rações, fármacos e cosméticos. Diante do aumento da demanda por carotenoides, estima-se que o mercado mundial movimentará vultosas quantias nos próximos anos. Considerando este fato, no cenário nacional, pode haver a elevação das importações, enquanto as exportações poderão se manter como nos últimos seis anos, com valores irrisórios, uma vez que são escassos os investimentos no desenvolvimento tecnológico de produção de carotenoides no Brasil.

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Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine

Cited by 274 publications

References 75 publications

Organic Agriculture 3.0 is innovation with research

Organic Agriculture 3.0 is innovation with research

Are salty liquid food flavorings in vitro antitumor substances?

Carotenoids: Properties, Applications and Market

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