Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents

Čihák, Rostislav; Srb, V

doi:10.1016/0165-1218(83)90103-9

Cited by 38 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, using in vivo experiments (a micronuclear test in mice) additionally confirmed the clastogenicity of quinoxaline 1,4-dioxides [ 22 ]. Thus, olaquindox ( 102 , Figure 17 ) induces chromosome aberrations when administered orally at a dose of 100 mg/kg, while carbadox ( 101 , Figure 17 ) exhibits the same effect at a dose of 800 mg/kg [ 189 ]. Nevertheless, in contrast to the derivatives 101 and 102 , the agricultural agent cyadox ( 104 , Figure 17 ) did not show a damaging effect on chromosomes, even at a dose of 1200 mg/kg.…”

Section: Toxicological Properties Of Quinoxaline 14-dioxidesmentioning

confidence: 99%

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Buravchenko,

Shchekotikhin

2023

Pharmaceuticals

View full text Add to dashboard Cite

N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse biological properties. The high reactivity and tendency to undergo various rearrangements have piqued the interest of synthetic chemists in heterocycles with N-oxide fragments. Quinoxaline 1,4-dioxides are an example of an important class of heterocyclic N-oxides, whose wide range of biological activity determines the prospects of their practical use in the development of drugs of various pharmaceutical groups. Derivatives from this series have found application in the clinic as antibacterial drugs and are used in agriculture. Quinoxaline 1,4-dioxides present a promising class for the development of new drugs targeting bacterial infections, oncological diseases, malaria, trypanosomiasis, leishmaniasis, and amoebiasis. The review considers the most important methods for the synthesis and key directions in the chemical modification of quinoxaline 1,4-dioxide derivatives, analyzes their biological properties, and evaluates the prospects for the practical application of the most interesting compounds.

show abstract

Section: Toxicological Properties Of Quinoxaline 14-dioxidesmentioning

confidence: 99%

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Buravchenko,

Shchekotikhin

2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

N‐(2‐Hydroxyethyl)‐3‐methyl‐2‐chinoxalincarboxamid‐1,4‐dioxid (Olaquindox) [MAK Value Documentation in German language, 1994]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 20. Lieferung, Ausgabe 1994 Der Artikel enthält folgende Kapitel: Anwendung als Masthilfsmittel Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik Erfahrungen beim Menschen Tierexperimentelle Befunde und in‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

show abstract

Olaquindox [MAK Value Documentation, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Published in the series Occupational Toxicants , Vol. 9 (1998) The article contains sections titled: Use as a feed additive Toxic Effects and Modes of Action Mechanisms of Action Toxicokinetics Absorption and elimination Distribution Metabolism Effects in Man Effects on Animals Acute toxicity Subacute, subchronic and chronic toxicity Effects on skin and mucous membranes Allergenic effects Reproductive toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

show abstract

Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents

Cited by 38 publications

References 10 publications

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

N‐(2‐Hydroxyethyl)‐3‐methyl‐2‐chinoxalincarboxamid‐1,4‐dioxid (Olaquindox) [MAK Value Documentation in German language, 1994]

Olaquindox [MAK Value Documentation, 1998]

Contact Info

Product

Resources

About