Cytogenetic Effects Of Aqueous Extracts Of The Medicinal Plant Paico (Chenopodium Multifidum L.)

Abstract

The cytogenetic effects of aqueous extracts of Chenopodium multifidum L. (Paico) were determined by addition of the extracts and fractions to human lymphocyte cultures. Toxicity was evaluated by analysis of chromosomal aberrations (CA), sister chromatid exchange (SCE), mitotic (MI) and replication (RI) indexes. The results showed an increase in CA frequency in cultures exposed to infusion, an increase in SCE frequency when the cultures were exposed to both infusion and decoction, no modification in the CPK values either in the decoction or in the infusion, and a decrease in the MI of lymphocyte cultures exposed to the decoction. These results suggested genotoxic effects of "Paico" aqueous extracts.

Argentine folk medicine: Genotoxic effects of Chenopodiaceae family

“…In previous works (Gadano et al, 2000(Gadano et al, , 2002, the cyto and genotoxic effect of the methylene chloride fraction (MC) obtained from the aqueous extracts of both aromatic Chenopodium species was shown. This suggests that active principles responsible for the cytotoxic effect of the species would be present mainly in the MC fraction.…”

Cytotoxic and genotoxic effects of aqueous extracts of five medicinal plants on Allium cepa Linn.

“…Despite the profound therapeutic advantages possessed by some of the plants, some constituents of medicinal plants have been shown to be potentially toxic, carcinogenic and teratogenic (Moody et al, 1999;Gadano et al, 2000Gadano et al, , 2002Gadano et al, , 2006Effraim et al, 2001;Teixera et al, 2003;Paes-Leme et al, 2005).…”

Herbal Medicines: Cytotoxic Effects of Chenopodiaceae Species Used in Argentinian Folk Medicine

“…A cytotoxic effect of both medicinal herbs was observed, evidenced by the decrease of the MI (Tables 2 to 5). In previous works, we concluded that neither C. multifidum nor C. ambrosioides induced any change in replication index values (Gadano et al, 2000(Gadano et al, , 2002, so it could be concluded that the aqueous extracts of C. ambrosioides and C. multifidum induced cellular death. Other evaluation of the potential cytotoxic effect was done with a nonaromatic species of the same family (C. album).…”