Cytogenetic damage in workers from a coal-fired power plant

Çelık, Mustafa; Dönbak, Lale; Ünal, Fatma; Yüzbaşıoğlu, Deniz; Aksoy, Hüseyin; Yılmaz, Serkan

doi:10.1016/j.mrgentox.2006.11.003

Cited by 61 publications

(26 citation statements)

References 30 publications

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“…Donbak et al (2005) reported significantly enhanced sister chromatid exchanges, and chromatid and chromosomal-type aberrations among coal miners with increase in occupational working years. Similarly, Celik et al (2007) reported elevated frequencies of sister chromatid exchanges and micronuclei in coal-fired power plant workers over a period of time.…”

Section: Resultsmentioning

confidence: 94%

Chromosome aberrations in workers of beach sand mineral industries

Meenakshi

Mohankumar

2013

Radioprotection

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Beach Sand Mining (BSM) is a profitable industry earning a sizable income for thecountry by way of foreign exchange. The Indian coast is rich in rare earths such as ilmenite, rutile, leucoxene, zircon, garnet and sillimanite, and is invariably associated with radioactive monazite. Due to the nature of the separation processes involved and the manual handling, workers in these factories are continuously being exposed to suspended particles containing naturally occurring radioactive materials. An attempt was made to estimate DNA damage using a chromosome aberration assay to monitor radiation effects in workers of BSM industries in India. The study group comprised 27 BSM workers and 20 controls. Percentage yields of dicentrics, acentric fragments and chromatid breaks observed in the control group were 0.058 ± 0.017, 0.073 ± 0.03 and 0.22 ± 0.112, respectively. Percentage yields of dicentrics + centric rings, acentric fragments and chromatid breaks observed in the BSM group were 0.029 ± 0.01 (P value 0.19), 0.24 ± 0.06 (P value 0.006) and 0.455 ± 0.06 (P value 0.0004), respectively. Elevated levels of fragments and chromatid aberrations are suggestive of low-dose radiation effects and also chemically-induced DNA damage.

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Section: Resultsmentioning

confidence: 94%

Chromosome aberrations in workers of beach sand mineral industries

Meenakshi

Mohankumar

2013

Radioprotection

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“…Some biomonitoring studies found positive association of age (Ozkul et al,1997;Moretti et al, 2000), sex (Betti et al, 1994;Bajpayee et al, 2002;Fenech et al, 2003), smoking (Burgaz et al, 1999;Hoffmann et al, 2005), alcohol intake (Ramirez et al, 2002) and tobacco chewing (Nair et al, 1991;Trivedi et al, 1993) while some studies observed no association of age (Zhu et al, 1999;Konapaka et al, 2003), sex (Anderson et al, 1993;Zhu et al, 1999;Konapaka et al, 2003), smoking (Moller et al, 2006), alcohol intake (Celik et al, 2007;Martinez-Valenzuela et al, 2009) with genetic damage. In our study, we did not observe any significant association of age, sex and consumption habits (smoking and alcohol use) with genetic damage.…”

Section: Discussionmentioning

confidence: 99%

CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers

Giri

Yadav²,

Kumar

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: It is well known that polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene have carcinogenic properties and may cause many types of cancers in human populations. Genetic susceptibility might be due to variation in genes encoding for carcinogen metabolizing enzymes, such as cytochrome P-450 (CYP450). Our study aimed to investigate the effect of genetic polymorphisms of CYP1A1 (m1 and m2) on genetic damage in 115 coaltar workers exposed to PAHs at their work place. Methods: Genetic polymorphisms of CYP1A1 were determined by the PCR-RFLP method. Comet and buccal micronucleus assays were used to evaluate genetic damage among 115 coal tar workers and 105 control subjects. Results: Both CYP1A1 m1 and CYP1A1 m2 heterozygous and homozygous (wt/mt+mt/mt) variants individually as well as synergistically showed significant association (P<0.05) with genetic damage as measured by tail moment (TM) and buccal micronuclei (BMN) frequencies in control and exposed subjects. Conclusion: In our study we found significant association of CYP1A1 m1 and m2 heterozygous (wt/mt)+homozygous (mt/mt) variants with genetic damage suggesting that these polymorphisms may modulate the effects of PAH exposure in occupational settings.

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“…Brazil has large mineral coal reserves and uses this matrix to produce energy, especially in the south region, even though it is known that coal rejects harm human health and the environment, whether they are from mining or from burning in thermal power plants (Celik et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Tools used to estimate soil quality in coal combustion waste areas

Júnior

Vargas

2014

An. Acad. Bras. Ciênc.

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Soil is a highly complex environmental compartment that has suffered with the contamination of substances of various origins. Among the main activities that affect soil quality are power generation activities that use fossil fuels, such as mineral coal. Environmental protection agencies encourage scientific investigations using tools described in legal devices or standard protocols to evaluate the potential of coal as a pollutant, especially in places that have large reserves of this mineral like the state of Rio Grande do Sul. The aim of this study was to characterize the leached extracts of different soils from an area influenced by coal waste, to classify them according to the guideline values for groundwater described in CONAMA's n. 420/2009, and to estimate the effects of the leachates ingestion in DNA mutation rates. The volume of soil needed to induce a 100% increase in the spontaneous mutation rate varied between 129.3 and 1544.1 mg of soil among the soils studied. Metals such as Mn, Pb, Cd and Ni surpassed the investigation limits for groundwater at least in one soil sample. The results showed that there can be transfer of soil contaminants to groundwater and soil intake in the area could contribute to the increased mutagenic risk.

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Cytogenetic damage in workers from a coal-fired power plant

Cited by 61 publications

References 30 publications

Chromosome aberrations in workers of beach sand mineral industries

Chromosome aberrations in workers of beach sand mineral industries

CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers

Tools used to estimate soil quality in coal combustion waste areas

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