Abstract:3433
The development of Ph− clones with new cytogenetic abnormalities has been reported among CML patients with complete cytogenetic remission (CCR) following diverse therapies such as Interferon and Imatinib (Gleevec). The etiologies for these abnormalities have not been characterized and have been attributed to drug effect, or underlying genetic instability in the bone marrow cells preceding or concomitant to the development of CML.
Here we report on 31 patients in CCR who, in a… Show more
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