Cytogenetic Analysis of Subcutaneous Angiolipoma: Further Evidence Supporting Its Difference from Ordinary Pure Lipomas

Sciot, Raf; Åkerman, Måns; Cin, Paola Dal; Wever, Ivo De; Fletcher, Christopher D.�M.; Mandahl, Nils; Mertens, Fredrik; Mitelman, Felix; Rosaí, Juan; Rydholm, Anders; Tallini, Giovanni; Berghe, Herman Van den; Vanni, Roberta; Willén, Helena

doi:10.1097/00000478-199704000-00010

Cited by 83 publications

(56 citation statements)

References 9 publications

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“…Neither atypia, pleomorphism or mitotic figures or karyotypical abnormalities were found [4]. Sciot et al's [82] analysis of the karyotype in 20 angiolipomas revealed that all were normal; the authors speculate that a normal karyotype supports the theory of angiolipomas as a reactive or hamartomatous lesion. They also suggest that the vascular proliferation could be a primary event in the development of these tumors, and the adipose tissue, a secondary, albeit prominent, component.…”

Section: Discussionmentioning

confidence: 94%

Spinal extradural angiolipoma: report of two cases and review of the literature

2009

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Spinal angiolipomas are benign uncommon neoplasm composed of mature lipocytes admixed with abnormal blood vessels. They account for only 0.04-1.2% of all spinal tumors. We report two cases of lumbar extradural angiolipoma and review previously reported cases. We found 118 cases of spinal epidural angiolipoma (70 females and 48 males; age range 1.5-85 years, mean 44.03) spanning from 1890 to 2006. Prior to diagnosis 40.6% of the patients had weakness of the lower limbs. The interval between the initial symptoms and tumor diagnosis ranged from 1 day to 17 years (mean 20.2 months). Except for four cases diagnosed at autopsy, 109 patients underwent surgery and gross-total resection was performed in 79 cases (72.4%). Spinal angiolipomas are tumors containing angiomatous and lipomatous tissue, predominantly located in the mid-thoracic region. All angiolipomas show iso-or hyperintensity on T1-weighted images and hyperintensity on T2-weighted images and most lesions enhance with gadolinium administration. The treatment for spinal extradural angiolipomas is total surgical resection and no adjuvant therapy should be administered.

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Section: Discussionmentioning

confidence: 94%

Spinal extradural angiolipoma: report of two cases and review of the literature

2009

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“…21) Normal karyotypes in a study of 20 patients with angiolipoma suggest the lesion is reactive or hamartomatous. 27) Angiolipoma may constitute an intermediate entity in the spectrum of hemangiomas and lipomas. The more invasive infiltrating type of spinal angiolipoma would then represent a shift towards the hemangioma end of the spectrum.…”

Section: Discussionmentioning

confidence: 99%

Spinal Angiolipoma-Case Report-

Chotai

Hur

Moon

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 69-year-old male presented with a rare spinal angiolipoma manifesting as history of back pain, and numbness in both lower limbs, which progressed over a period of 5 years. Total T10-T12 laminectomy was performed and the tumor was removed en bloc. The symptoms gradually improved postoperatively. Spinal angiolipoma is an uncommon benign extradural tumor of spine, which accounts for 0.14-1.2% of all spinal tumors and is a rare cause of spinal cord compression. Recognition of this entity is crucial as a benign and curable cause of paraplegia and back pain.

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“…For this reason, it has been proposed that they may represent hamartomas rather than true neoplasms. 7 Histopathologically, they are composed of a variable proportion of mature fat cells and thin-walled capillaries. The vascular component constitutes up to 90% or more of the lesions, and fibrin thrombi are frequently observed.…”

Section: Discussionmentioning

confidence: 99%

Sonographic Appearance of Subcutaneous Angiolipomas

Choong¹

2004

Journal of Ultrasound in Medicine

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Case ReportA 37-year-old man had multiple subcutaneous lumps on the torso and all extremities. These first became noticeable after puberty and had slowly increased in size and number over the years. They were variable in size, ranging from several millimeters to several centimeters. The lumps were firm, partially mobile, and smooth on palpation. The larger ones had a bosselated surface. Some were mildly tender on compression. Sonographic assessment of several of the larger lumps was requested before cosmetic surgery. The lumps were imaged with a high-resolution L12-5 linear array transducer on an HDI 5000 machine (Philips Medical Systems, Bothell, WA). These all had a similar appearance on sonography. The lumps were well defined and located in the subcutaneous layer. They had a predominantly hyperechoic appearance, which clearly distinguished them from the adjacent hypoechoic adipose tissue (Figure 1). Small, patchy hypoechoic areas were noted within the larger masses. No posterior acoustic enhancement was seen. The larger masses showed sparse internal vascularity on color Doppler imaging. Excisional biopsy of 16 lumps showed the typical features of angiolipomas, with a mixture of adipocytes and a variable amount of angiomatous tissue.

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Cytogenetic Analysis of Subcutaneous Angiolipoma: Further Evidence Supporting Its Difference from Ordinary Pure Lipomas

Cited by 83 publications

References 9 publications

Spinal extradural angiolipoma: report of two cases and review of the literature

Spinal extradural angiolipoma: report of two cases and review of the literature

Spinal Angiolipoma-Case Report-

Sonographic Appearance of Subcutaneous Angiolipomas

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