Cytogenetic analysis of first trimester pregnancy loss

Petracchi, Florencia; Colaci, Daniela; Igarzabal, Laura; Gadow, Enrique C.

doi:10.1016/j.ijgo.2008.10.014

Cited by 32 publications

(22 citation statements)

References 3 publications

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“…It is well known that the most common aetiology for a sporadic and recurrent miscarriage is a chromosomal anomaly . On the other hand, more than half of recurrent miscarriage cases are considered idiopathic after extensive work‐up in the couple…”

Section: Introductionmentioning

confidence: 99%

Cost‐effectiveness of cytogenetic evaluation of products of conception by chorionic villus sampling in recurrent miscarriage

2017

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Section: Introductionmentioning

confidence: 99%

Cost‐effectiveness of cytogenetic evaluation of products of conception by chorionic villus sampling in recurrent miscarriage

2017

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“…Early pregnancy loss (EPL) remains a significant cause of reproductive wastage in mammals [1][2][3][4][5] but the underlying aetiologies are often unknown [6,7]. A retrospective study in horses showed a speculative cause for EPL was found in just 16% of cases [8].…”

Section: Introductionmentioning

confidence: 99%

A method for isolating and culturing placental cells from failed early equine pregnancies

et al. 2016

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“…Fetal chromosomal abnormalities are the primary etiology of SM, especially aneuploidies. [ 1 2 ] Chromosome aneuploidy and polyploidy consist of more than 96% of chromosomal abnormalities in spontaneous abortion and X, Y, 13, 16, 18, 21, and 22 are frequently involved. Although conventional karyotyping is the gold standard of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Aneuploidy in Early Miscarriage and its Related Factors

Chen

Wang

Lan

et al. 2015

Chinese Medical Journal

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Background:Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes.Methods:A total of 840 chorionic samples from spontaneous abortion were collected and examined by FISH. We analyzed the incidence and type of abnormal cases and sex ratio in the samples. We also analyzed the relationship between the rate of aneuploidy and parental age, the rate of aneuploidy between recurrent abortion and sporadic abortion, the difference in incidence of aneuploidy between samples from previous artificial abortion and those from no previous induced abortion.Results:A total of 832 samples were finally analyzed. 368 (44.23%) were abnormal, in which 84.24% (310/368) were aneuploidies and 15.76% (58/368) were polyploidies. The first was trisomy16 (121/310), followed by trisomy 22, and X monosomy. There was no significant difference in the rate of aneuploidy in the advanced maternal age group (≥35 years old) and young maternal age group (<35 years old). However, the rate of trisomy 22 and the total rate of trisomies 21, 13, and 18 (the number of trisomy 21 plus trisomy 13 and trisomy 18 together) showed significantly different in two groups. We found no skewed sex ratio. There was no significant difference in the rate of aneuploidy between recurrent miscarriage and sporadic abortion or between the samples from previous artificial abortion and those from no previous artificial abortion.Conclusions:Aneuploidy is a principal factor of miscarriage and total parental age is a risk factor. There is no skewed sex ratio in spontaneous abortion. There is also no difference in the rate of aneuploidy between recurrent abortion and sporadic abortion or between previous artificial abortion and no previous induced abortion.

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Cytogenetic analysis of first trimester pregnancy loss

Cited by 32 publications

References 3 publications

Cost‐effectiveness of cytogenetic evaluation of products of conception by chorionic villus sampling in recurrent miscarriage

Cost‐effectiveness of cytogenetic evaluation of products of conception by chorionic villus sampling in recurrent miscarriage

A method for isolating and culturing placental cells from failed early equine pregnancies

Aneuploidy in Early Miscarriage and its Related Factors

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