Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature

Koutsimpelas, Dimitrios; Brieger, Jürgen; Heinrich, Ulf‐Rüdiger; Torzewski, Michael; Sommer, Clemens; Mann, Wolf J.

doi:10.1007/s00405-011-1658-z

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…More than half of MTT cases are associated with neurofibromatosis type 1 (NF-1) (7, 8). Furthermore, genetic analysis revealed some autosomal aberrations could lead to the occurrence and recurrence of MTT (9).…”

Section: Discussionmentioning

confidence: 99%

Intracranial Malignant Triton Tumor in Children: A Case Report

Hu¹,

He²,

Wang³

et al. 2021

Iran J Radiol

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: Malignant triton tumor (MTT) is a rare, aggressive type of tumor that commonly originates from mesenchymal tissue and is mainly found in adults. Herein, we report a single case of a 12-year-old boy diagnosed with intracranial MTT. This report presents the clinical features and imaging findings of MTT. The 12-year-old patient consulted the hospital due to intermittent dizziness and headache. Computed tomography (CT) showed low-density space-occupying lesion in the left parietal fossa. Magnetic resonance imaging (MRI) showed a mass shadow with slightly long T1 and long T2 signal intensity in the same area. Contrast enhanced MRI (CE-MRI) showed obvious enhancement of the lesion. He was diagnosed with meningioma and underwent surgery. Postoperative histopathological examination diagnosed the lesion as MTT. Two months after the operation, CT examination showed tumor recurrence. He then underwent local radiotherapy and chemotherapy, and unfortunately, died six months later. Intracranial MTT should be considered as one of the differential diagnoses of intracranial meningiomas. CT and MRI are of great significance in the identification of lesion location, invasion range, and degree of malignancy. Final diagnosis of intracranial MTT requires histopathological examination. MTT has a poor prognosis, and surgical resection of the tumor is the preferred treatment. Intervention after early diagnosis is the key to improve the outcome of patients.

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Section: Discussionmentioning

confidence: 99%

Intracranial Malignant Triton Tumor in Children: A Case Report

Hu¹,

He²,

Wang³

et al. 2021

Iran J Radiol

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“…Comparative genomic hybridization analysis of leiomyosarcomas (LMS) has detected losses in numerous loci, including the PTEN suppressor gene (10q) in 20 of 29 cases examined and Rb suppressor gene (13q) in 17 of 29 cases . Oncogenic gain was identified in 16 of 29 cases on locus 17p , which interestingly has been implicated in malignant triton tumors . To this end, the role of molecular pathology as a diagnostic tool has been limited .…”

Section: Leiomyosarcomamentioning

confidence: 99%

Molecular diagnostics in soft tissue sarcomas and gastrointestinal stromal tumors

Smith

Coleman

Bridge

et al. 2015

Journal of Surgical Oncology

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Soft tissue sarcomas are rare malignant heterogenous tumors of mesenchymal origin with over fifty subtypes. The use of hematoxylin and eosin stained sections (and immunohistochemistry) in the morphologic assessment of these tumors has been the bane of clinical diagnosis until recently. The last decade has witnessed considerable progress in the understanding and application of molecular techniques in refining the current understanding of soft tissue sarcomas and gastrointestinal stromal tumors beyond the limits of traditional approaches. Indeed, the identification of reciprocal chromosomal translocations and fusion genes in some subsets of sarcomas with potential implications in the pathogenesis, diagnosis and treatment has been revolutionary. The era of molecular targeted therapy presents a platform that continues to drive biomarker discovery and personalized medicine in soft tissue sarcomas and gastrointestinal stromal tumors. In this review, we highlight how the different molecular techniques have enhanced the diagnosis of these tumors with prognostic and therapeutic implications.

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“…Most of them showed rather complex cytogenetic deviations, although some genetic aberrations appear to be common [20-25]. Koutsimpelas et al firstly analyzed the genomic imbalance of a case of MTT using comparative genomic hybridization (CGH) [26]. The results demonstrated the involvement of oncogenes located at chromosomes 1, 16, 17, 19, and 22.…”

Section: Case Presentationmentioning

confidence: 99%

A rare case of malignant triton tumor in the cerebellopontine angle

et al. 2012

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Malignant triton tumor (MTT) is defined as malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Intracranial MTT is extremely rare, and only four cases have been reported in the literature. Here, we report a case of MTT occurring in the cerebellopontine angle, and describe its histopathological characteristics, immunohistochemical features, and prognosis.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1336227313684480

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Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature

Cited by 7 publications

References 23 publications

Intracranial Malignant Triton Tumor in Children: A Case Report

Intracranial Malignant Triton Tumor in Children: A Case Report

Molecular diagnostics in soft tissue sarcomas and gastrointestinal stromal tumors

A rare case of malignant triton tumor in the cerebellopontine angle

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