Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China

Liu, Qingjie; Lü, Xue; Hua, Zhao; Chen, Sen; Wang, Mingming; Bai, Yongli; Zhang, Shulan; Jiao, Feng; Zhang, Zhaohui; Chen, Deqing; Ma, Li; Jia, Ting-zhen; Liang, Li

doi:10.1016/j.mrgentox.2013.05.015

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…Five years post-irradiation, the dic + r levels were 29%, 22%, and 44% of the initial levels. A series of studies showed that chromosomal aberrations in peripheral blood lymphocytes (dic + r) maintained a stable level nearly one month after irradiation and then gradually decreased over time [6,[8][9][10][11][12][13]. Our results show that the greater the initial radiation dose, the faster it aberrations decreased during recovery, which is consistent with previous reports.…”

Section: Discussionsupporting

confidence: 91%

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Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally irradiated by a cobalt-60 source

Wang

Zhang

et al. 2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Discussionsupporting

confidence: 91%

“…Slide preparation for FISH was performed similarly to the G-banding method. FISH was performed with probes of chromosome 1, 2 and/or 4 according to previous literature [6].…”

Section: Fluorescence In Situ Hybridization (Fish)mentioning

confidence: 99%

Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally irradiated by a cobalt-60 source

Wang

Zhang

et al. 2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…In particular, there is human in vivo data demonstrating this. A study of a pregnant woman and her then in utero child, both heavily exposed (to several Gy) from an orphan 60 Co source, demonstrated a progressive decline in MN in mother and daughter over the period from 41 days to 16 years after the accident [42]. This may also explain our generally null findings in relation to radiation exposure from the Chornobyl accident, last exposure from which occurred between 12 and 18 years prior to buccal cell sampling.…”

Section: Discussionmentioning

confidence: 99%

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Bazyka¹,

Finch²,

Ilienko³

et al. 2017

Environ Health

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BackgroundIonizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk. There are well-documented associations of micronuclei with ionizing radiation dose in some radiation-exposed groups, although not all. That associations are not seen in all radiation-exposed groups may be because cells with micronuclei will not generally pass through mitosis, so that radiation-induced micronuclei decay, generally within a few years after exposure.MethodsBuccal samples from a group of 111 male workers in Ukraine exposed to ionizing radiation during the cleanup activities at the Chornobyl nuclear power plant were studied. Samples were taken between 12 and 18 years after their last radiation exposure from the Chornobyl cleanup. The frequency of binucleated micronuclei was analyzed in relation to estimated bone marrow dose from the cleanup activities along with a number of environmental/occupational risk factors using Poisson regression adjusted for overdispersion.ResultsAmong the 105 persons without a previous cancer diagnosis, the mean Chornobyl-related dose was 59.5 mSv (range 0–748.4 mSv). There was a borderline significant increase in micronuclei frequency among those reporting work as an industrial radiographer compared with all others, with a relative risk of 6.19 (95% CI 0.90, 31.08, 2-sided p = 0.0729), although this was based on a single person. There was a borderline significant positive radiation dose response for micronuclei frequency with increase in micronuclei per 1000 scored cells per Gy of 3.03 (95% CI -0.78, 7.65, 2-sided p = 0.1170), and a borderline significant reduction of excess relative MN prevalence with increasing time since last exposure (p = 0.0949). There was a significant (p = 0.0388) reduction in MN prevalence associated with bone X-ray exposure, but no significant trend (p = 0.3845) of MN prevalence with numbers of bone X-ray procedures.ConclusionsThere are indications of increasing trends of micronuclei prevalence with Chornobyl-cleanup-associated dose, and indications of reduction in radiation-associated excess prevalence of micronuclei with time after exposure. There are also indications of substantially increased micronuclei associated with work as an industrial radiographer. This analysis adds to the understanding of the long-term effects of low-dose radiation exposures on relevant cellular structures and methods appropriate for long-term radiation biodosimetry.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0273-x) contains supplementary material, which is available to authorized users.

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“…In the present study, three persons accidentally exposed to 60 Co gamma rays were evaluated through analyses of UCAs and the MN assay. CBMN represents UCAs that disappear with time, along with dic + r [16]. In this follow-up study, the data show that the frequencies of CBMN decreased to the normal level, 6 months after the accident.…”

Section: Discussionmentioning

confidence: 59%

Eight-year follow-up study of three individuals accidentally exposed to 60Co radiation: Chromosome aberration and micronucleus analysis

Wang

et al. 2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China

Cited by 11 publications

References 22 publications

Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally irradiated by a cobalt-60 source

Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally irradiated by a cobalt-60 source

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Eight-year follow-up study of three individuals accidentally exposed to 60Co radiation: Chromosome aberration and micronucleus analysis

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