Cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia

Sendi, Halima Sennana; Elghezal, Hatem; Temmi, Henda; Hichri, Haifa; Gribaa, Moez; El-Omri, Halima; Meddeb, B.; Othmane, Tarek Ben; Elloumi, Moez; Sarkhosh, Ali

doi:10.1016/s0003-3995(02)01098-5

Cited by 12 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,[17][18][19][20][21][22][23][24][25][26] The results of this study compared with several population-based and regional studies are detailed in Table 3. These represent most large-scale published studies that deal exclusively with de novo AML.…”

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Almentioning

confidence: 99%

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cheng

Wang

et al. 2009

Leukemia

View full text Add to dashboard Cite

Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid leukemia (AML) patients are available. We examined the karyotypic patterns in 1432 de novo AML patients from a single center in China and compared our data with reports from other regions of the world. Chromosomal abnormalities were detected in 746 (58%) cases. The most frequent cytogenetic abnormality was t(15;17), detected in 14% of successful cases, followed by t(8;21) in 8%, and t(9;22), þ 21 and þ 8 each in 2%. The mean age of patients with a translocation karyotype was significantly younger than that of patients with normal, deletion or trisomy karyotypes. A higher incidence of AML M3 and a lower frequency of M4 were observed in the Asian population and the frequencies of certain cytogenetic aberrations were different from those in the earlier reports. Population-based age-specific incidences of AML were calculated and compared with those in western reports.

show abstract

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Almentioning

confidence: 99%

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cheng

Wang

et al. 2009

Leukemia

View full text Add to dashboard Cite

show abstract

“…Slides contain no metaphases so the interphase FISH analysis for the RUNX1/RUNX1T1 probe showed one normal orange (RUNX1T1) and one normal green (RUNX1) signals on normal chromosomes 8 and 21 and one orange-green fusion signal corresponding to the co-localization of RUNX1T1 and RUNX1 signals on probably the rearranged chromosome 8 as, thus confirming the presence of the RUNX1/RUNX1T1 fusion gene in this translocation. FISH results revealed also the presence of a green signal on the derivative chromosome 21 and of one small orange signal (RUNX1T1) which would be probably located der (9) (Figure 1(B)).…”

Section: Resultsmentioning

confidence: 99%

“…BM mononuclear cells were cultured for 48 hours and chromosome preparations were made by an R-banding method. Twenty metaphases from each specimen were analyzed and karyotypes as described previously [9] in accordance with the International System for Human Cytogenetic Nomenclature [10].…”

Section: Cytogenetic Analysis Of Bone Marrow Cellsmentioning

confidence: 99%

New Variant Translocation (8;9;21)(q22;p24;q22) in a Patient with Granulocytic Sarcoma Concurrent with Acute Myeloid Leukemia

Gmidène¹,

Ines²,

Sondes³

et al. 2014

OJBD

View full text Add to dashboard Cite

Granulocytic sarcoma is a form of acute myeloid leukemia which may occur in any anatomical site. Isolated pancreatic granulocytic sarcoma is however, extremely rare. Translocation t(8;21) is the most common cytogenetic abnormality found in leukemia patients with granulocytic sarcoma and is associated with a relatively good prognosis when treated with chemotherapy. Variants of the t(8;21) are uncommon and account for approximately 3% to 4% of acute myeloid leukemia associated with t(8;21) and are rarely described in acute myeloid leukemia cases associated with granulocytic sarcoma. We report here a patient with acute myeloid leukemia and a novel variant t(8;9;21)(q22;p24;q22) with suspected granulocytic sarcoma in pancreas. A dual-color fluorescence in situ hybridization analysis with RUNX1T1 and RUNX1 probes, revealed the presence of an RUNX1/RUNX1T1 fusion signal in this translocation. To the best of our knowledge, a variant of t(8;21) in GS was rarely described and the involvement of the 9q22 region is the first time described here even in isolated AML-M2. We conclude that further accumulation of similar cases is needed and that genetic exploring of variants of t(8;21) may be helpful for a better understanding of molecular pathogenetic mechanism.

show abstract

“…A search of the Cancer Genome Anatomy Project database (http://cgap.nci.nih.gov/Chromosomes/Mitelman) for all cases of AMKL with chromosomal abnormalities or breakpoints revealed that t(1;5)(q21;p13) detected in our patient has not been reported in patients with AMKL (13). t(1;5) with different breakpoints such as (q32;p15) and (q32;q12) has been reported as a part of complex chromosomal abnormalities in AMKL (14, 15). Unbalanced translocation between 1q and 5q is defined in AML‐M0 and therapy‐related myelodysplastic syndrome (16).…”

Section: Discussionmentioning

confidence: 99%

Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). Case report

Bozkurt

Berrak

Tuğtepe

et al. 2008

APMIS

View full text Add to dashboard Cite

Acute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).

show abstract

Cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia

Cited by 12 publications

References 15 publications

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

New Variant Translocation (8;9;21)(q22;p24;q22) in a Patient with Granulocytic Sarcoma Concurrent with Acute Myeloid Leukemia

Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). Case report

Contact Info

Product

Resources

About