Cytogenetic Abnormalities in Three Patients with B-Cell Prolymphocytic Leukemia

Solé, Françesc; Woessner, S; Espinet, Blanca; Lloveras, Elisabet; Florensa, Lourdes; Pérez-Losada, A.; Vilà, R M; Besses, Carles; Sans-Sabrafén, J

doi:10.1016/s0165-4608(97)00358-0

Cited by 12 publications

(4 citation statements)

References 19 publications

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“…Our present results confirmed previous case reports in which a CK was frequent in B-PLL. 24,27,34 The frequency of a CK in B-PLL (73% in the present study) is higher than that reported in BL (34%), 35 MCL (40%-60%), 36,37 MZL (53%), 38 and CLL at diagnosis (15%) [39][40][41][42] and is similar to that observed in high-risk CLL. 43 Whereas t(MYC) is the main abnormality in B-PLL (62%), it is rare in other chronic B-cell disorders (ie, ,5% in MCL, MZL, and CLL).…”

Section: Discussionsupporting

confidence: 78%

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Chapiro

Pramil

Diop

et al. 2019

Blood

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Section: Discussionsupporting

confidence: 78%

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Chapiro

Pramil

Diop

et al. 2019

Blood

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“…A Medline search for t(11;14) positive B‐PLL identified 14 cases reported between 1983 and 1999 (Table II) (Pittman & Catovsky, 1983; Brito‐Babapulle et al , 1987, 1992; Louie et al , 1987; Galiegue‐Zouitina et al , 1994; Kobayashi et al , 1995; Takashima et al , 1997; Solé et al , 1998; Matutes et al , 1999; Dunphy & Perkins, 2001; Schlette et al , 2001; Wong et al , 2002). Thereafter no further cases appeared, and reports of the nucleolated blastoid variant or prolymphocytoid variant of MCL began to appear (Dunphy & Perkins, 2001; Schlette et al , 2001; Wong et al , 2002).…”

Section: Discussionmentioning

confidence: 99%

B‐prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia

et al. 2004

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SummaryWe reviewed eight cases that were diagnosed before 1995 with B-prolymphocytic leukaemia (B-PLL) harbouring t(11;14)(q13;q32) and/or cyclin D1 staining. Thirteen B-PLL patients without t(11;14) were selected as controls. Peripheral blood, bone marrow and histological sections were re-examined without cytogenetic information. Final diagnosis was made using morphology, cytogenetics, immunophenotype and immunohistochemistry. Clinical characteristics were similar for both groups except for younger age, male predominance and extranodal involvement in cases with t(11;14). CD5 was more frequently positive in the t(11;14)+ group (80%) than in the t(11;14)) group (31%). Surface membrane immunoglobulin was strongly expressed by all t(11;14)+ cases, but only 45% of t(11;14)) cases. Histopathological and cytological review of cases with t(11;14) showed an infiltrate with a mixture of cells, some resembling prolymphocytes and others with mantle cell lymphoma (MCL) morphology. Blood films of cases with t(11;14) showed features suggestive of B-PLL in three, and in others, a mixture of cells resembling MCL and nucleolated ones; none corresponded to the blastoid form of MCL. We suggest that 'B-PLL' with t(11;14) may represent a splenomegalic form of MCL evolving with leukaemia. These cases illustrate the importance of tissue diagnosis with cyclin D1 staining and fluorescence in situ hybridization analysis in B-cell leukaemia with prolymphocytic features.

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“…Only a few cytogenetic studies have been reported in B-PLL because of the rarity of the disease and the difficulty of obtaining prolymphocytes in metaphase. [50][51][52][53] Use of B-cell mitogens might increase the detection rate of cytogenetic changes. Complex karyotypic changes are common.…”

Section: How I Diagnose B-pllmentioning

confidence: 99%