Abstract:Background:The T-cell engager antibody blinatumomab (Blincyto T M ) represents a promising rescue therapy for relapsed/refractory CD19 + acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3 + T-lymphocytes and leukemic CD19 + B-cells, resulting in a granzyme B (GzB)-mediated specific lysis of leukemic cells. Methods: Aim of the study was to provide evidence that variability in blinatumomab response could have a g… Show more
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