Cytodiagnosis of Extramedullary Plasmacytomas

Goel, Garima; Rai, Sharada; Naik, Ramadas; Gupta, Akshita; Baliga, Poornima; Sinha, Ruchi

doi:10.1159/000325031

Cited by 19 publications

(19 citation statements)

References 12 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a few studies have reported the cytomorphologic findings associated with SEP, to our knowledge, no publications have discussed the liquid‐based cytologic findings of SEP . Additionally, the aspiration cytology findings of thyroidal SEP have only been discussed in a few prior reports .…”

mentioning

confidence: 99%

Liquid‐based cytologic findings of solitary extramedullary plasmacytoma in thyroid: A case report identified with fine‐needle aspiration cytology

Lee

Jung

Chung

et al. 2014

Diagnostic Cytopathology

View full text Add to dashboard Cite

Preoperative cytologic diagnosis of solitary extramedullary plasmacytoma (SEP) presents a challenge to cytopathologists because this tumor rarely occurs as a primary thyroid malignant neoplasm. In this report, we provide the first description of liquid-based cytomorphologic findings of SEP observed on fine-needle aspiration biopsy (FNAB) of the thyroid. A 56-year-old woman with a history of Hashimoto thyroiditis presented with a growing nodule in the thyroid. The liquid-based preparation obtained from FNAB showed numerous dispersed plasmacytoid cells with occasional loosely cohesive aggregates of tumor cells. Cells were round to oval in shape, with eccentrically located nuclei. Hyalinized perinuclear vacuoles were found in the cytoplasm of the tumor cells. Initial cytological findings, including those of immunochemistry using a cell block preparation, were consistent with plasmacytoma. Histopathological examination subsequent to thyroidectomy revealed a plasmacytoma in the thyroid. Plasma cell neoplasms were not concurrently detected in tissues other than the thyroid. On the basis of preoperative FNAB findings, a specific diagnosis of SEP in the thyroid can be difficult because this tumor is rare. Moreover, diagnosis is impeded because SEP in the thyroid resembles other, more common thyroid lesions, including both benign and malignant neoplasms. Careful cytomorphologic examination and supportive studies may be required to fully confirm a diagnosis of SEP.

show abstract

mentioning

confidence: 99%

Liquid‐based cytologic findings of solitary extramedullary plasmacytoma in thyroid: A case report identified with fine‐needle aspiration cytology

Lee

Jung

Chung

et al. 2014

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…In some cases, the cytology smears of myeloma show a mixture of plasmablasts and plasma cells in various stages of maturation with nuclear atypia, moderate pleomorphism and basophilic cytoplasm. [4–6] The first case showed the presence of anaplasia, increased plasmablasts and less number of mature plasma cells, and therefore the cytological evaluation was challenging in comparison to the second case where there were more of mature plasma cells.…”

Section: Casementioning

confidence: 99%

Cytodiagnosis of multiple myeloma presenting as chest wall swellings

Jena

2012

J Cytol

View full text Add to dashboard Cite

“…The majority (80%) occurs in the head and neck region (Regezi et al), in particularly, in the nasopharynx, paranasal sinuses and tonsils (75%). The EMP occurs less commonly, in the oropharynx (12%) (Goel et al, 2010). It accounts for around 4% of non-epithelial neoplasms of the nasal cavity, paranasal sinuses, and nasopharynx (Regezi et al), occurring mainly in the fifth and sixth decades of life, with a higher prevalence in men (Gross et al, 2004;Nasr Ben Ammar et al).…”

Section: Extramedullary Plasmacytoma (Emp)mentioning

confidence: 99%

Plasmacytoma in the Oral Cavity: A Case Report

Barros

Sevilha

Amantéa

et al. 2011

Int. J. Odontostomat.

View full text Add to dashboard Cite

The plasma cell neoplasms may present in soft tissue as extramedullary plasmacytoma (EMP), in bone as a solitary plasmacytoma of bone (SPB), or as part of the multifocal disseminated disease multiple myeloma (MM). The EMP is rare, comprising around 3% of all plasma cell neoplasm. The majority (80%) occurs in the head and neck region. In this study we report a case of a man, 70 years old, melanoderm, with a lesion of the oral cavity. Upon physical examination, a lesion was found that extended throughout the posterior upper alveolar ridge, as far as the maxillary tuber on the left side, extending towards the palate. Radiographic examination, complementary laboratory exams were performed. Based on the conclusive symptoms of plasmacytoma, the patient was referred to the hematology service for treatment with local radiotherapy. The patient responded satisfactorily to the treatment, and after 15 months, all clinical symptoms of the lesion in the oral cavity had disappeared.

show abstract

Cytodiagnosis of Extramedullary Plasmacytomas

Cited by 19 publications

References 12 publications

Liquid‐based cytologic findings of solitary extramedullary plasmacytoma in thyroid: A case report identified with fine‐needle aspiration cytology

Liquid‐based cytologic findings of solitary extramedullary plasmacytoma in thyroid: A case report identified with fine‐needle aspiration cytology

Cytodiagnosis of multiple myeloma presenting as chest wall swellings

Plasmacytoma in the Oral Cavity: A Case Report

Contact Info

Product

Resources

About