Cytocompatibility of Plasma Sprayed Bioceramic Coatings

Abstract

In this paper, the Al2O3, ZrO2, TiO2, wollastonite, dicalcium silicate and their composite coatings were deposited onto Ti-6Al-4V substrates by an atmosphere plasma spray system. The rat osteoblasts were seeded onto the surface of the coatings to evaluate the growth behavior of osteoblasts on different implant materials. Scanning electron microscopy was used to observe the morphologies of the osteoblasts seeded on the surface of the coating for different time. The SEM observation indicated the osteoblasts are difficult to survive and proliferate on the Al2O3 coating surface. Osteoblasts can survive and proliferate slowly on the TiO2 and ZrO2 coating surface. Osteoblasts grow and proliferate very well on the surface of the wollastonite and dicalcium silicate coating, which present the two coatings possess excellent cytocompatibility. The addition of wollastonite and dicalcium silicate into ZrO2 and TiO2 can improve their cytocompatibility.

Grafting Collagen on the Plasma Sprayed Titania Coating Treated by Sodium Hydroxide

“…However, their biocompatibility is not always satisfactory. Our previous work pointed that the plasma sprayed titania coatings allow the cellular survival and slow proliferation, but they can not accelerate the cell adhesion and proliferation [2], which frequently result in loose connection with the bone tissues, indicating the necessity for further modification to improve their biocompatibility.…”