Cytocompatibility of electrospun poly‐L‐lactic acid membranes for Bruch's membrane regeneration using human embryonic stem cell‐derived retinal pigment epithelial cells
Naghmeh Abbasi,
Helen O'Neill
Abstract:Cell replacement therapy is under development for dry age‐related macular degeneration (AMD). A thin membrane resembling the Bruch's membrane is required to form a cell‐on‐membrane construct with retinal pigment epithelial (RPE) cells. These cells have been differentiated from human embryonic stem cells (hESCs) in vitro. A carrier membrane is required for cell implantation, which is biocompatible for cell growth and has dimensions and physical properties resembling the Bruch's membrane. Here a nanofiber electr… Show more
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